MTHFR, COMT & Methylation: Fixing the Biochemistry Behind Anxiety and Brain Fog
Levelheaded Mind
12,063 views
Feeling anxious, foggy, or moody—and nothing seems to help? It could be your methylation. In this video, I explain what methylation is, how it affects your brain, and why understanding genes like MTHFR and COMT can be the key to unlocking better mental health. Learn how nutrition, lifestyle, and personalized genetic insights can optimize your mood, energy, and focus.
00:47 What Is Methylation?
01:44 Why Does Methylation Matter for Mental Health?
02:36 Methylation and Epigenetics?
04:05 Role of COMT in Methylation
06:38 Optimizing Your Methylation through Nutrition
07:45 Lifestyle Factors That Significantly Impact Methylation
09:12 Practical Tips
09:56 Supplementation
10:18 Conclusion
🧬DNA Testing packages: https://2ly.link/261YY
🧪 Mental Health Lab Testing: https://2ly.link/261YZ
💊Personalized supplements- https://tidd.ly/45B3elj
📚 Recommended Reading: https://www.levelheadedmind.com/books
🎥 This video was edited by:
Rahul Kanchi LinkedIn: rahul-kanchi
🚑 If you are in a mental health crisis, please dial 9-8-8 from the U.S. Or text HOME to 741741 and connect to a crisis counselor.
You can find a list of international crisis lines here: https://blog.opencounseling.com/suici...
References:
Bottiglieri T. (2005). Homocysteine and folate metabolism in depression. Progress in neuro-psychopharmacology & biological psychiatry, 29(7), 1103–1112. https://doi.org/10.1016/j.pnpbp.2005....
Deth, R., Muratore, C., Benzecry, J., Power-Charnitsky, V. A., & Waly, M. (2008). How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis. Neurotoxicology, 29(1), 190–201. https://doi.org/10.1016/j.neuro.2007....
Lax, E. (2022). DNA Methylation as a Therapeutic and Diagnostic Target in Major Depressive Disorder. Frontiers in Behavioral Neuroscience, 16. https://doi.org/10.3389/fnbeh.2022.75...
Papakostas, G. I., Shelton, R. C., Zajecka, J. M., Etemad, B., Rickels, K., Clain, A., Baer, L., Dalton, E. D., Sacco, G. R., Schoenfeld, D., Pencina, M., Meisner, A., Bottiglieri, T., Nelson, E., Mischoulon, D., Alpert, J. E., Barbee, J. G., Zisook, S., & Fava, M. (2012). L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. The American journal of psychiatry, 169(12), 1267–1274. https://doi.org/10.1176/appi.ajp.2012...
Yavich, L., Forsberg, M. M., Karayiorgou, M., Gogos, J. A., & Männistö, P. T. (2007). Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(38), 10196–10209. https://doi.org/10.1523/JNEUROSCI.066...
Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own healthcare provider for proper diagnosis and treatment.
Note: This video is not sponsored. Some of the links provided are affiliate links, meaning I may earn a small commission from purchases made through those links.
20 Comments
I use methyl b compex as an adjunct to my medication plus other nutritions such as vitamin d and high epa fish oil.
I have to mention that yes some days I tried double dose of methyl b complex and I noticed more agitation.
I wasn't aware that maybe it could be from this double dosing and I assumed that I had a bad day in my neurotransmitter function.
Those informations seem very valuable
MTHFR, COMT & Methylation: Fixing the Biochemistry Behind Anxiety and Brain Fog
Levelheaded Mind
12,063 views
Feeling anxious, foggy, or moody—and nothing seems to help? It could be your methylation. In this video, I explain what methylation is, how it affects your brain, and why understanding genes like MTHFR and COMT can be the key to unlocking better mental health. Learn how nutrition, lifestyle, and personalized genetic insights can optimize your mood, energy, and focus.
00:47 What Is Methylation?
01:44 Why Does Methylation Matter for Mental Health?
02:36 Methylation and Epigenetics?
04:05 Role of COMT in Methylation
06:38 Optimizing Your Methylation through Nutrition
07:45 Lifestyle Factors That Significantly Impact Methylation
09:12 Practical Tips
09:56 Supplementation
10:18 Conclusion
🧬DNA Testing packages: https://2ly.link/261YY
🧪 Mental Health Lab Testing: https://2ly.link/261YZ
💊Personalized supplements- https://tidd.ly/45B3elj
📚 Recommended Reading: https://www.levelheadedmind.com/books
🎥 This video was edited by:
Rahul Kanchi LinkedIn: rahul-kanchi
🚑 If you are in a mental health crisis, please dial 9-8-8 from the U.S. Or text HOME to 741741 and connect to a crisis counselor.
You can find a list of international crisis lines here: https://blog.opencounseling.com/suici...
References:
Bottiglieri T. (2005). Homocysteine and folate metabolism in depression. Progress in neuro-psychopharmacology & biological psychiatry, 29(7), 1103–1112. https://doi.org/10.1016/j.pnpbp.2005....
Deth, R., Muratore, C., Benzecry, J., Power-Charnitsky, V. A., & Waly, M. (2008). How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis. Neurotoxicology, 29(1), 190–201. https://doi.org/10.1016/j.neuro.2007....
Lax, E. (2022). DNA Methylation as a Therapeutic and Diagnostic Target in Major Depressive Disorder. Frontiers in Behavioral Neuroscience, 16. https://doi.org/10.3389/fnbeh.2022.75...
Papakostas, G. I., Shelton, R. C., Zajecka, J. M., Etemad, B., Rickels, K., Clain, A., Baer, L., Dalton, E. D., Sacco, G. R., Schoenfeld, D., Pencina, M., Meisner, A., Bottiglieri, T., Nelson, E., Mischoulon, D., Alpert, J. E., Barbee, J. G., Zisook, S., & Fava, M. (2012). L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. The American journal of psychiatry, 169(12), 1267–1274. https://doi.org/10.1176/appi.ajp.2012...
Yavich, L., Forsberg, M. M., Karayiorgou, M., Gogos, J. A., & Männistö, P. T. (2007). Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(38), 10196–10209. https://doi.org/10.1523/JNEUROSCI.066...
Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own healthcare provider for proper diagnosis and treatment.
Note: This video is not sponsored. Some of the links provided are affiliate links, meaning I may earn a small commission from purchases made through those links.