Overmethylation Symptoms No One Warned You About (MTHFR, COMT & More)
Levelheaded Mind
15,444 views
Are your B-vitamins making you more anxious, wired, or sleepless instead of better? In this video, I break down what many clinicians call overmethylation, what’s actually happening in your biochemistry, how it connects to genes like MTHFR and COMT, and why some people react badly to methylfolate, methyl B12, SAMe, and “methylation support” stacks.
We’ll walk through common symptoms (anxiety, insomnia, irritability, feeling overstimulated), the key genes and pathways involved, and practical steps to calm your system down: adjusting methyl donors, supporting “buffer” nutrients like magnesium, glycine, and B6, and lowering your total stress load. I also touch on how low-dose niacin can sometimes act as a short-term “methyl sponge” when you’ve clearly overdone it, and I’ll have a dedicated niacin deep-dive video coming soon.
This video is for education only and isn’t medical advice. Do not start or stop any medications or supplements based solely on this video. Use it as a framework to talk with your own clinician or to explore genetic-based mental health coaching options linked below.
🧬DNA Testing packages: https://2ly.link/261YY
🧪 Mental Health Lab Testing: https://2ly.link/261YZ
💊Personalized supplements- https://tidd.ly/45B3elj
📚 Recommended Reading: https://www.levelheadedmind.com/books
🎥 This video was edited by:
Rahul Kanchi LinkedIn: rahul-kanchi
🚑 If you are in a mental health crisis, please dial 9-8-8 from the U.S. Or text HOME to 741741 and connect to a crisis counselor.
You can find a list of international crisis lines here: https://blog.opencounseling.com/suici...
References:
Bekdash R. A. (2023). Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection. International journal of molecular sciences, 24(3), 2346. https://doi.org/10.3390/ijms24032346
McCaddon, A., & Miller, J. W. (2023). Homocysteine—a retrospective and prospective appraisal. Frontiers in Nutrition, 10. https://doi.org/10.3389/fnut.2023.117...
Team, M. A. (2025, July 18). Overmethylation: Signs and Solutions. Allergy Research Group. https://allergyresearchgroup.com/blog...
Vaccaro, J. A., & Naser, S. A. (2022). The Role of Methyl Donors of the Methionine Cycle in Gastrointestinal Infection and Inflammation. Healthcare, 10(1), 61. https://doi.org/10.3390/healthcare100...
Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own healthcare provider for proper diagnosis and treatment.
Note: This video is not sponsored. Some of the links provided are affiliate links, meaning I may earn a small commission from purchases made through those links.
20 Comments
Also i´m estrogen dominant with too less progesterone but also..i don´t tolerate progesterone (bumps up cortisol ! And or affects GABA, which i don´t tolerate? cause one minute i´m down super depressed next second i´m agressive af). What can i do about that too?
Overmethylation Symptoms No One Warned You About (MTHFR, COMT & More)
Levelheaded Mind
15,444 views
Are your B-vitamins making you more anxious, wired, or sleepless instead of better? In this video, I break down what many clinicians call overmethylation, what’s actually happening in your biochemistry, how it connects to genes like MTHFR and COMT, and why some people react badly to methylfolate, methyl B12, SAMe, and “methylation support” stacks.
We’ll walk through common symptoms (anxiety, insomnia, irritability, feeling overstimulated), the key genes and pathways involved, and practical steps to calm your system down: adjusting methyl donors, supporting “buffer” nutrients like magnesium, glycine, and B6, and lowering your total stress load. I also touch on how low-dose niacin can sometimes act as a short-term “methyl sponge” when you’ve clearly overdone it, and I’ll have a dedicated niacin deep-dive video coming soon.
This video is for education only and isn’t medical advice. Do not start or stop any medications or supplements based solely on this video. Use it as a framework to talk with your own clinician or to explore genetic-based mental health coaching options linked below.
🧬DNA Testing packages: https://2ly.link/261YY
🧪 Mental Health Lab Testing: https://2ly.link/261YZ
💊Personalized supplements- https://tidd.ly/45B3elj
📚 Recommended Reading: https://www.levelheadedmind.com/books
🎥 This video was edited by:
Rahul Kanchi LinkedIn: rahul-kanchi
🚑 If you are in a mental health crisis, please dial 9-8-8 from the U.S. Or text HOME to 741741 and connect to a crisis counselor.
You can find a list of international crisis lines here: https://blog.opencounseling.com/suici...
References:
Bekdash R. A. (2023). Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection. International journal of molecular sciences, 24(3), 2346. https://doi.org/10.3390/ijms24032346
McCaddon, A., & Miller, J. W. (2023). Homocysteine—a retrospective and prospective appraisal. Frontiers in Nutrition, 10. https://doi.org/10.3389/fnut.2023.117...
Team, M. A. (2025, July 18). Overmethylation: Signs and Solutions. Allergy Research Group. https://allergyresearchgroup.com/blog...
Vaccaro, J. A., & Naser, S. A. (2022). The Role of Methyl Donors of the Methionine Cycle in Gastrointestinal Infection and Inflammation. Healthcare, 10(1), 61. https://doi.org/10.3390/healthcare100...
Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own healthcare provider for proper diagnosis and treatment.
Note: This video is not sponsored. Some of the links provided are affiliate links, meaning I may earn a small commission from purchases made through those links.