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The Supercomputers Designing the Future of Psychedelic Science | VICE | Blueprint

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Understanding how simple molecules reshape human perception requires stepping into the cutting edge of psychopharmacology. Hamilton Morris begins by inspecting LSD bound to a brain receptor in Dr. Bryan Roth's lab, traces wild ergot fungi, meets with legendary chemist Dr. David Nichols to discuss a lifetime of synthesis, and looks at supercomputers screening billions of virtual compounds for future medicines.

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In Hamilton's Pharmacopeia, join Hamilton Morris as he investigates the extraordinary chemistry, scientific history, and societal impact of the world's most misunderstood psychoactive substances. From laboratory experiments to complex organic syntheses, discover the fascinating science, neuroscience, and chemical engineering behind these incredible molecules.

This film was first broadcast: 2021

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20 Comments

@JakeMcIntyre-i9o 1 month ago

Fell in love with a pigeon what am I watching hahaha

@henryhawke 1 month ago (edited)

In case anyones interested in the Ultra-LSD research thats happened since then: Theres been an absolute explosion of incredibly promising new compounds such as: two novel antidepressants and neuroplasticity drugs called (R)-69 and (R)-70. Both compounds demonstrated potent antidepressant activity equivalent to traditional selective serotonin reuptake inhibitors (SSRIs) like fluoxetine (Prozac) while requiring as little as 1/40th of the standard dose. Also, both molecules promoted robust dendritogenesis (the growth of new dendrites) and spinogenesis (the formation of neuronal spines) in cortical regions. The most incredible thing about this is that theres near one BILLION different possible structural combinations. Absolutely wonderful times to be alive.

@kickmcmelon18 1 month ago

That dude is quick af 😂 "you just dropped acid"

@JustBassphaceJoe 1 month ago (edited)

Hamilton is a great influence of mine. If I don't get to research/make psychedelic compounds legally someday, I'll have failed myself. Preparing to go back to school but for Laboratory Chem Tech, Let's hope I can get my foot in the door! My state recently got approved for Psychedelic Therapy for Mental Health, Addiction & Treatment Resistant Depression! I'm tryna get in on that for a carreer.

@DixonCyderbush-e2c 1 month ago

Farmer: This is the ergot fungus
Hamilton: Wow, That's horrible. Can you show me some more. ( Puts it in his pocket 😂)

@S0-102 1 month ago

Hamilton really is master of his craft, he knows what questions matter to interviewees and not just for viewers or company, when to just stay quiet knows his chemistry and history. Love it when you can see people actually care about what they are doing and love their work. I hope he goes on like Sir Attenborough of chemistry and human experience.

@powersv2 1 month ago

Super impressed by the research into schizophrenia. The bird lady drilling into her skull was all the way out there.

@SanjayBabaganoosh 3 weeks ago

"The world is ripe to learn. But jaded to be instructed."

Goddamn that hits hard...Holy crap, that's deep...

@ChuckyBalboaOnline 1 month ago

Holy shit, that woman has endured so much pain and yet is so strong and full of life. Bless her heart

@20CentMan 1 month ago

I remember Teslas had a bird buddy too.
I like the metaphor of knowing the “language of the birds” as the path to the secrets of nature

@jamieharr4459 1 month ago

I sprinted to the comment section as soon as she started talking about the pigeon..

@ElixerofEgypt 1 month ago

When the hallucinations caused by these drugs get very intense, there seems to be this feeling of existing without your body and it's as if you're being purged of your nihilism.

@Louiethegoldfalconberg 1 month ago

The quality of these mini documentaries is absolutely insane, Hamilton please do not change a single thing. Please

@brettmoore3194 1 month ago (edited)

I'm sure those meal worms probably died from the 18ga needle pushing through their bodies😂

@SBAMSRG 1 month ago (edited)

she cracked a pigeon i am dead laughing
(edit: holy smokes chill out here, everything is good, i genuinely think that woman is amazing, and i am clinically as much crazy as her)