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The ONLY science-backed anti-aging skincare video you’ll ever need to watch

Natalie O'Neill

38,679 views

The internet will have you spending hundreds on anti-ageing skincare and supplements that science barely supports.

In this video, I cover everything that is robustly science-backed for preventing premature skin ageing - the non-negotiables you should have nailed before considering anything else, plus the nice-to-haves that have decent-ish evidence behind them but shouldn't be solely relied upon. We're covering skincare AND lifestyle habits.

This is the video to watch before you book Botox, before you spend money on expensive actives, and before you let the internet convince you that premature aging skin is complicated. It isn’t. Science only backs a handful of things - and they’re simpler than you think.

In this video:

The science-backed skincare non-negotiables
Nice-to-haves with decent evidence
Is PDRN actually worth it?
Habits that science says genuinely slow premature ageing
What to have sorted before considering Botox

00:00 Intro - what's covered
03:20 Skincare essentials
11:24 Nice-to-haves but not to rely on
15:27 Is PDRN worth using?
21:20 Essential habits for aging well
27:39 How far can skincare really take you?
31:52 The checklist

Videos mentioned in this video:

My skincare routine (morning) - My morning skincare routine: step by step ...
My skincare routine (evening) - My evening skincare routine: products & steps
FREE Retinoid Guide - https://stan.store/natalieoneilll/p/h...
Ask Me Anything on Substack - https://substack.com/chat/5168294
ALL Product Recommendations - https://shopmy.us/shop/natalieoneill
Instagram - Instagram: natalieoneill
TikTok - www.tiktok.com/@natalie_oneillll

Not sponsored. All opinions are my own.

20 Comments

@Pipikatchus_Baby 1 day ago

Perfect speaking speed as well lmaooo

@luizakhachatryan6282 1 day ago

Taking this opportunity to thank you! I used to fall for influencer marketing all the time, constantly thinking I needed more products to improve my skin. You've completely changed the way I approach skincare and helped me realize how important it is to keep things simple, be intentional with every product, and not overdo it. My skin has genuinely never been better, and that means even more considering how many dermatologists I've seen who left me disappointed. Your advice has made such a difference, and I'm truly grateful! ❤

@Danielle_roberts898 9 hours ago

I truly suggest to speak about Microneedling. It is possible to delay aging and reverse a LOT just through Microneedling. No procedure that I have done in my life was as helpful as the high-quality derma pen I got for around 200$. I am 48 and I look younger than I was when I were 35.

@EldestDaughterRanch 1 day ago

I watch every video you post multiple times to make sure it sinks in (and I love the way you communicate, it’s oddly soothing for me). Thank you for helping my skin become the best it’s ever been!

@TheTheLeeloo 1 day ago

You saying in a tiktok to let the retinoid DRY before applying moisturizer on top was the game changer for me!! It works so much better now!!

@Pipikatchus_Baby 1 day ago

because of you, I started AzA and it has been a game changer for my texture and pores and redness!!! never going back again!!

@Alexia-kd5el 1 day ago

Finding you on YouTube randomly one day literally advanced my skincare game.I resonate with the way you express yourself and are so knowledgeable.Thank you Natalie!

@alisaajeseni 23 hours ago

Perfect speed! ❤ There are many YouTubers I love but I have to watch them at 1.25 or 1.5 the speed in order to get through the video MENTALLY 😅

@sadams7394 1 day ago

Thank you for that video! Every time I start overthinking my skincare routine I watch one if your videos and it helps me to stay consistent and saves me alot of money. Your speaking speed is perfect

@Kyubey12345 23 hours ago

Thank you so much for this! I just turned 29 and was overhelemed starting to learn about this whole skincare thing.

@Rasel9394rs-b7f 7 hours ago

I really liked how this science-backed anti-aging skincare and lifestyle video by Natalie O'Neill cut through social media trends to focus on fundamental, evidence-based practices—breaking down the essential skincare holy trinity (retinoids, sunscreen, and proper hydration layering), evaluating popular trends like PDRN, discussing lifestyle habits like sleep, sugar, and dairy, and outlining the actual limits of skincare versus treatments like Botox in this video.

I’ve created an alternative professional thumbnail specifically for this video that I’d love to share with you. What would be the easiest way to send it for your review?

@dora-xg2gt 1 day ago

Genuinely thank you for such an informative video, this is the type of information I was severely lacking. Very appreciated <3

@filomena3417 4 hours ago

As an autistic girl I relate to your earplugs experience so much!

@EmmaWest-h7w 4 hours ago

Seeing something like copper peptides with scientific studies to back up their effects on collagen is a pleasant surprise compared to another ranking of vitamin C products. The missing element in videos like this is the fact that many cases of so-called “aging” skin are actually caused by chronic breakouts or rosacea that alter the skin’s texture due to bacterial infection. Parallel Health performs personalized microbiome testing at home and uses it to create customized phage-based topical treatments specifically for the bacteria found in each individual test.

@mordan4686 1 day ago

Sleep all night... Can't do, I have a cat 😅

@emihyrule 1 day ago

This is amazing!! Your content is truly the best there is. You’re honest, science backed, funny, and cover almost every topic possible. It’s amazing! I’m so grateful I found you. Thank you for taking the time out of your day to always tell us how to honestly take care of our skin!

@BaghdadSana 1 day ago

Hi Natalie, I love love love how you explain scientific facts in a way that is very easy to digest. Thanks to you, I’ve safely started using Differin. I can’t wait to see results in a few months.

I love that I now fully understand the process of what’s going on in/on my skin when using my products and can also support people around me or just refer them to your videos! Super helpful and great work !!

@4328898 1 day ago

The annoying thing is there realistically probably IS something better than tret that exists right now, due to advancements in skincare science, but due to the lack of longitudinal studies we don't know yet. It could well be pdrn!

@MsSznur 1 day ago

I had facial nerve paralysis on one side of my face recently. My face did not move on one side for over 3 weeks. I saw my wrinkles disappear on that side in a week which was crazy. My face movement is restored now but my forehead and smile lines did not set in again yet so it does look weird. But if there is something that would make me do botox is that I saw how it would look already even though it was not on purpose.

@ScoutMum 9 hours ago

So glad I found your channel. So fed up with influencers who don’t know jack but talk like experts on everything, freely putting out garbage information and causing people to spend thousands of dollars and doing so much damage to their skin. Thank you for evidence based reporting 👍