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Can estrogen cream really make your face look younger? In this video I break down the growing trend of using estrogen cream on facial skin, including the important differences between estradiol and estriol, what happens to skin as estrogen signaling declines during menopause, and what the clinical studies actually show about wrinkles, hydration, elasticity and collagen.
We’ll look at vaginal estrogen cream versus compounded facial estriol, estrogen receptor alpha vs beta, the concentrations used in published studies, and why formulation and dose matter. I also discuss systemic absorption, the finding of increased prolactin in one study, melasma and pigmentation concerns, and who should speak with their physician before considering topical estrogen for the face.
Facial estrogen for skin aging is an off-label use in the United States, and estriol is not an FDA-approved drug in the U.S. This video is educational and is not a substitute for individualized medical care.
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Schmidt JB, Binder M, Demschik G, Bieglmayer C, Reiner A. Treatment of skin aging with topical estrogens. International Journal of Dermatology. 1996;35(9):669-674.
This is your key study: 59 women, six months, 0.3% estriol vs 0.01% estradiol. Both groups showed improvement in hydration, elasticity/firmness and wrinkle depth; biopsies were performed in a subset. PMID: 8876303. PubMed
PubMed: Schmidt et al. 1996

Creidi P, Faivre B, Agache P, et al. Effect of a conjugated oestrogen (Premarin) cream on ageing facial skin: a comparative study with a placebo cream. Maturitas. 1994;19(3):211-223.
Randomized, double-blind study of 54 women treated for 24 weeks. Conjugated estrogen produced significantly greater improvement in skin thickness and fine wrinkles than placebo. PMID: 7799828. PubMed
PubMed: Creidi et al. 1994

Fuchs KO, Solis O, Tapawan R, Paranjpe J. The effects of an estrogen and glycolic acid cream on the facial skin of postmenopausal women: a randomized histologic study. Cutis. 2003;71(6):481-488.
In 65 women, 0.01% estradiol increased epidermal thickness by approximately 23% after six months; the study also examined glycolic acid and the combination. PMID: 12839261. PubMed
PubMed: Fuchs et al. 2003

Silva LA, Carbonel AAF, Moraes ARB, et al. Collagen concentration on the facial skin of postmenopausal women after topical treatment with estradiol and genistein: a randomized double-blind controlled trial. Gynecological Endocrinology. 2017;33(11):845-848.
A randomized, double-blind study of 30 postmenopausal women found increases in facial type I and III collagen after topical treatment, with the estradiol group outperforming topical genistein. PMID: 28508697. PubMed
PubMed: Silva et al. 2017
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FTC: Some links included in this description might be affiliate links. If you purchase a product through one of them, I will receive a commission (at no additional cost to you). I truly appreciate your support of my channel. Thank you for watching! Video is not sponsored. DISCLAIMER: This video does not contain any medical or health related diagnosis or treatment advice. Content provided on this YouTube Channel is for informational purposes only. For any medical or health related advice, please consult with a physician or other healthcare professionals. Further, information about specific products or treatments within this video are not to diagnose, treat, cure or prevent disease.
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0:00 Estrogen Cream on Your Face?
0:43 Estradiol vs Estriol
0:55 What Estrogen Does to Your Skin
1:49 Estrogen Receptors: Alpha vs Beta
2:42 Estradiol Explained
2:55 FDA-Approved Estrogen vs Estriol
4:19 The Problem With Vaginal Cream on the Face
5:35 Estriol Explained
6:21 Compounded Estrogen Creams for the Face
7:35 What Do the Clinical Studies Show?
8:56 Which Estrogen Do I Prefer for Facial Skin?
9:41 The 59-Woman Estriol vs Estradiol Study
10:22 Safety, Absorption and Prolactin
11:02 Who Should Be Cautious?
12:07 Facial Estrogen vs Systemic HRT
12:46 Off-Label Use and How It Is Prescribed
13:41 Free Personalized Skin Analysis