Has your GLP-1 stopped working — or does it just feel different?

Maybe you're taking Zepbound, Wegovy, Mounjaro, semaglutide, or tirzepatide and things had been going well. You lost weight. Your hunger decreased. The food noise quieted down. Maybe you even reached maintenance.

Then something changed.

The food noise came back. You're hungrier. You're thinking about food more often. The scale is creeping upward. And suddenly you're wondering:

Is my GLP-1 not working anymore?

In this episode of Weight & Measure, Mike Donnelly-Boylen and guest co-host Deb Cooperman sit down with obesity medicine physicians Dr. Lindsay Ogle and Dr. Brianna Bingham to break down what may actually be happening when a GLP-1 medication starts to feel different.

They discuss whether your body can adapt to GLP-1 medications, what can contribute to returning hunger or food noise, and why a change on the scale doesn't automatically mean your medication has failed.

You'll learn what to look at when something changes, including:

• GLP-1 dose and timing
• Returning hunger and food noise
• Weight gain or weight reoccurrence
• Sleep and stress
• Nutrition and hydration
• Physical activity
• New medications or medication changes
• Corticosteroids and other drugs that can affect weight
• Thyroid function and other potential medical changes
• When lab testing may be worth discussing with your healthcare professional
• What to track before your next appointment
• What options may remain if you're already at your maximum tolerated dose

Mike and Deb also ask what comes next for people who have reached the limits of today's GLP-1 treatments, including emerging obesity medications and combination therapies such as retatrutide, CagriSema, and amylin-based treatments.

And perhaps most importantly: Does semaglutide or tirzepatide actually stop working over time?

If you've searched for “Why isn't my GLP-1 working anymore?”, “Why is my food noise back?”, “Why am I gaining weight on Zepbound?”, “Does Wegovy stop working?” or “What happens after reaching the maximum GLP-1 dose?”, this episode was made for you.

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⚠️ Medical disclaimer: Weight & Measure is for educational and informational purposes only. Nothing in this episode should be considered individualized medical advice or a substitute for care from your healthcare professional. Do not start, stop, or change a medication based solely on information discussed in this program.

#GLP1 #Zepbound #Wegovy #Tirzepatide #Semaglutide