Which GLP is best? I’ve tried all three. Here’s my honest take.
Kim Constable
24,144 views
Semaglutide, tirzepatide and retatrutide are often grouped together as though they are interchangeable. But after personally exploring all three, Kim’s experience with each one was very different.
In this full-length, audio-first episode of The Kim Constable Podcast, Kim shares the benefits she noticed, the side effects she experienced, where each compound appeared to help and which one she personally preferred.
Kim originally became interested in GLP-1s for reasons that extended beyond weight loss. At the time, she was struggling with persistent gluteal tendinopathy, joint pain, digestive discomfort, bloating, headaches, brain fog, broken sleep and the feeling that her body had changed dramatically during menopause.
That curiosity led her to explore semaglutide first, followed by tirzepatide and retatrutide.
Although the three are often discussed together, they target different combinations of pathways:
• Semaglutide primarily targets the GLP-1 receptor
• Tirzepatide targets the GLP-1 and GIP receptors
• Retatrutide targets the GLP-1, GIP and glucagon receptors
In this episode, Kim moves beyond the science and shares what each experience was actually like for her.
She discusses the changes she personally noticed in appetite, food noise, inflammation, digestion, sleep, energy, brain fog, body composition and weight maintenance. She also speaks candidly about the less desirable effects, including fatigue, headaches, digestive slowing and an unexpected pattern she observed after taking semaglutide.
Timestamps
00:00 – Why Kim recorded this personal follow-up episode
03:00 – Discovering semaglutide beyond weight loss
07:00 – Judgment around GLP use and Kim’s honest reason for trying it
11:30 – Menopause, inflammation, brain fog and digestive problems
16:30 – Changes Kim noticed in pain, digestion and morning headaches
21:30 – Sleep, appetite, food noise and weight maintenance
26:30 – Headaches, fatigue and individual dose sensitivity
29:30 – The unexpected herpes flare-up pattern Kim noticed
35:00 – Slower digestion, constipation and managing the downsides
38:00 – Tirzepatide: why Kim switched and how the experience differed
40:00 – Retatrutide: Kim’s personal experience with the triple agonist
45:00 – Semaglutide, tirzepatide and retatrutide compared
49:00 – Which one Kim personally preferred and final thoughts
Inside This Episode
• Why Kim originally explored semaglutide during menopause
• Her experience with inflammation, joint pain and gluteal tendinopathy
• The judgment she faced after discussing GLP use publicly
• Why she was also honest about wanting easier fat loss and maintenance
• How semaglutide, tirzepatide and retatrutide target different receptors
• Why targeting more pathways does not automatically make one option better
• The differences Kim noticed in appetite and food noise
• How the three experiences compared for inflammation and physical discomfort
• Changes she observed in digestion, sleep, headaches and brain fog
• Which effects felt significant and which were less impressive than expected
• Fatigue, headaches and digestive slowing
• The unexpected side-effect pattern Kim noticed while using semaglutide
• Why one person may respond very differently from another
• The difference between personal experience and clinical evidence
• Why nobody should copy another person’s dose or personal protocol
This is not a promotional review of one compound over another. It is Kim’s honest account of her personal experience with semaglutide, tirzepatide and retatrutide—including the benefits, limitations and unexpected downsides.
Kim’s experience is individual and should not be treated as evidence that another person will experience the same benefits, risks or side effects.
This episode is for educational and informational purposes only. Kim is not a doctor or licensed medical practitioner. Nothing discussed should be interpreted as medical advice, a diagnosis, prescribing guidance or instructions for purchasing, reconstituting, dosing or administering any compound.
Always consult an appropriately qualified healthcare professional before beginning, stopping or changing any medication or treatment. Some compounds discussed may be prescription medicines or investigational products depending on jurisdiction and current regulatory status.
🎧 This is a full-length audio podcast. Put your headphones on, make a cup of tea and settle in for Kim’s honest comparison of what changed, what didn’t and why the three experiences felt so different.
✨ Follow Kim Constable online for more honest conversations about menopause, fitness, health and longevity:
📺 YouTube: @kimconstableofficial
📸 Instagram: Instagram: thesculptedvegan
🎵 TikTok: TikTok: kimconstableofficial
🌐 Website: https://www.thesculptedvegan.com
#GLP1 #Semaglutide #Tirzepatide #Retatrutide #MenopauseHealth
20 Comments
Thx for the info
This was literally my experience from 2010 (41) to last year. Unrecognized menopause, misdiagnosed as Lyme disease. Had wicked fatigue and constant recurrences of oral herpes, flares of Epstein Barr, then 4 bouts of COVID with long haul, shingles. Not until last year did I realize it was menopause and getting adequate Estradiol/ Progesterone/Testosterone replacement is rebounding my immune system.
Which GLP is best? I’ve tried all three. Here’s my honest take.
Kim Constable
24,144 views
Semaglutide, tirzepatide and retatrutide are often grouped together as though they are interchangeable. But after personally exploring all three, Kim’s experience with each one was very different.
In this full-length, audio-first episode of The Kim Constable Podcast, Kim shares the benefits she noticed, the side effects she experienced, where each compound appeared to help and which one she personally preferred.
Kim originally became interested in GLP-1s for reasons that extended beyond weight loss. At the time, she was struggling with persistent gluteal tendinopathy, joint pain, digestive discomfort, bloating, headaches, brain fog, broken sleep and the feeling that her body had changed dramatically during menopause.
That curiosity led her to explore semaglutide first, followed by tirzepatide and retatrutide.
Although the three are often discussed together, they target different combinations of pathways:
• Semaglutide primarily targets the GLP-1 receptor
• Tirzepatide targets the GLP-1 and GIP receptors
• Retatrutide targets the GLP-1, GIP and glucagon receptors
In this episode, Kim moves beyond the science and shares what each experience was actually like for her.
She discusses the changes she personally noticed in appetite, food noise, inflammation, digestion, sleep, energy, brain fog, body composition and weight maintenance. She also speaks candidly about the less desirable effects, including fatigue, headaches, digestive slowing and an unexpected pattern she observed after taking semaglutide.
Timestamps
00:00 – Why Kim recorded this personal follow-up episode
03:00 – Discovering semaglutide beyond weight loss
07:00 – Judgment around GLP use and Kim’s honest reason for trying it
11:30 – Menopause, inflammation, brain fog and digestive problems
16:30 – Changes Kim noticed in pain, digestion and morning headaches
21:30 – Sleep, appetite, food noise and weight maintenance
26:30 – Headaches, fatigue and individual dose sensitivity
29:30 – The unexpected herpes flare-up pattern Kim noticed
35:00 – Slower digestion, constipation and managing the downsides
38:00 – Tirzepatide: why Kim switched and how the experience differed
40:00 – Retatrutide: Kim’s personal experience with the triple agonist
45:00 – Semaglutide, tirzepatide and retatrutide compared
49:00 – Which one Kim personally preferred and final thoughts
Inside This Episode
• Why Kim originally explored semaglutide during menopause
• Her experience with inflammation, joint pain and gluteal tendinopathy
• The judgment she faced after discussing GLP use publicly
• Why she was also honest about wanting easier fat loss and maintenance
• How semaglutide, tirzepatide and retatrutide target different receptors
• Why targeting more pathways does not automatically make one option better
• The differences Kim noticed in appetite and food noise
• How the three experiences compared for inflammation and physical discomfort
• Changes she observed in digestion, sleep, headaches and brain fog
• Which effects felt significant and which were less impressive than expected
• Fatigue, headaches and digestive slowing
• The unexpected side-effect pattern Kim noticed while using semaglutide
• Why one person may respond very differently from another
• The difference between personal experience and clinical evidence
• Why nobody should copy another person’s dose or personal protocol
This is not a promotional review of one compound over another. It is Kim’s honest account of her personal experience with semaglutide, tirzepatide and retatrutide—including the benefits, limitations and unexpected downsides.
Kim’s experience is individual and should not be treated as evidence that another person will experience the same benefits, risks or side effects.
This episode is for educational and informational purposes only. Kim is not a doctor or licensed medical practitioner. Nothing discussed should be interpreted as medical advice, a diagnosis, prescribing guidance or instructions for purchasing, reconstituting, dosing or administering any compound.
Always consult an appropriately qualified healthcare professional before beginning, stopping or changing any medication or treatment. Some compounds discussed may be prescription medicines or investigational products depending on jurisdiction and current regulatory status.
🎧 This is a full-length audio podcast. Put your headphones on, make a cup of tea and settle in for Kim’s honest comparison of what changed, what didn’t and why the three experiences felt so different.
✨ Follow Kim Constable online for more honest conversations about menopause, fitness, health and longevity:
📺 YouTube: @kimconstableofficial
📸 Instagram: Instagram: thesculptedvegan
🎵 TikTok: TikTok: kimconstableofficial
🌐 Website: https://www.thesculptedvegan.com
#GLP1 #Semaglutide #Tirzepatide #Retatrutide #MenopauseHealth