As a massive Spider-Man and long time TV On The Radio fan, hearing this fade into the opening of Brand New Day had me feeling like a kid at Christmas with a huge smile on my face.

It was such an incredible surprise that I actually wept tears of joy; it did help that the edible I ate kicked in at the same time.

Who’s here in 2026? I sure the fuck am.

Here’s my five-billionth comment about how absolutely incredible this performance was. That’s all.

Do they realise that they just pulled off arguably one of the greatest live music performances in tv history….it was stunning

Guys just went on late night and casually performed a version of the song that’s 100x better than the studio version. Legendary.

These guys look like a bunch of high school science teachers but they rock the fuck out.

This song, this band, its the climax of the feeling of being  alive, pure joy, pure punk, pure rock, 100% going forward and getting lost in that tune. Forget everything else in that moment just embrace it.

Greetings to all the new faces coming here after seeing the new spiderman movie. You can enjoy with us the best song in the world in its purest form.

They did not have to go that hard but I'm happy they did.

Holy shit. You can tell that the whole band is also surprised at how hard Tunde is going, but they completely rise to the occasion. This is one of those rare performances captured on video that is absolutely magnetic. Insanely good

I love how the bassist is totally oblivious to all the crazy business that is going on behind him

One of the most underrated bands in modern time

This will never get old. Send it to Mars.

All the folks coming here from the new spidey movie leave some respect for Gerard Smith, RIP.

One of the most awesome performances of music in human history.

Letterman was on the air for 30 years and the two performances of this song are nearly universally regarded as the greatest musical performances in his shows history.

Shout out to not only the band members themselves, but the audio techs as well.

This song is dedicated to my husband who passed 2yrs this month.. He was everything to me..'wolf like me ', how's the irony... R.I.P. PETER... till we meet again...💋....

always love how he casually puts the mic back on the stand as if he finished a poetry reading and not one of the greatest live performances of all time

This is the single greatest Letterman performance of all time.