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Is Sugar Making You Age Faster? The Surprising Link to Longevity | Dr. David Sinclair

Mark Hyman, MD

376,722 views

Sugar and aging are directly linked, but you do not need extreme restriction to improve your health. Learn how managing your fasting blood sugar can help you live longer.

This week, I’m joined by Dr. David Sinclair to explore the topic of longevity and anti-aging and how he reduced his own internal age by more than 20 years. D explains the biological connection between sugar consumption and the aging process. If you are interested in longevity tips, understanding your blood glucose levels is a vital starting point. We break down why consistent, moderate eating habits are often more sustainable and effective than drastic dietary changes.

By focusing on your fasting blood sugar, you can make informed decisions about your diet that support long-term health. We explore the evidence behind why reducing sugar intake is a powerful tool for longevity, providing a practical approach for anyone looking to optimize their lifespan without feeling deprived.

Subscribe for weekly health and longevity breakdowns, and comment below if you have questions about managing your sugar intake.

#Longevity #AntiAging #IntermittentFasting #DavidSinclair

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(0:00) Sugar's impact on aging, balanced diet, good vs. bad carbs, and exercise
(2:15) Benefits of sauna and cold stress
(4:54) Supplements, medications, and concerns about cholesterol and statins
(7:46) Monitoring health metrics and reversing chronic diseases through lifestyle changes
(10:14) Deleting senescent cells to improve healthspan
(13:38) Learning from long-lived organisms for human longevity
(15:37) Extending healthspan versus lifespan
(17:28) Economic and global benefits of healthier aging
(25:09) Understanding mitochondrial function in aging
(27:00) Resveratrol, NAD, and their impact on mitochondria and longevity
(37:33) Personal experiences with mitochondrial dysfunction and NAD’s impact
(43:31) Experimenting with NAD boosters for aging
(46:26) Introduction to "The Revolutionary Science of Why We Age and Why We Don't Have To"
(47:40) Sugar, sirtuins, and Dr. Hyman's personal aging journey
(50:20) Metformin and other interventions for aging
(53:33) Information theory of aging and the epigenome
(57:07) Reprogramming the body and importance of circadian rhythms
(1:00:32) Research on time-restricted eating and intermittent fasting
(1:05:04) Insulin resistance, eating times, and intermittent fasting benefits
(1:08:09) The importance of meal timing, chronobiology, and biological rhythms
(1:11:01) A perfect eating plan for a day
(1:13:11) Dr. Roizen’s routine for staying healthy and energetic
(1:16:20) Implementing wellness programs at Cleveland Clinic
(1:24:10) The benefits of large wellness incentives
(1:25:48) The concept of food pharmacies and their impact on health

20 Comments

@jeannevessard3510 2 years ago

My uncle talked about passing in his sleep for decades. One day he played golf and had lunch with his friends. He passed in his sleep that night at 73 years old. His wife thought he was still sleeping when she saw him in the morning but soon found out he had passed. He got his wish. Some years later his wife wanted to notified before she passed. Her daughter told me she was holding her mother's hand one morning and her mother told her she had been notified. She asked her daughter if she had paid the bills and the daughter said she had. Right after when she was still holding her mother's hand she felt the energy leave the hand. My cousin said her parents got their wishes. They passed the way they wanted.

@WayneL.L.Camick 3 years ago

eat one meal a day and not after 7 pm. I've done this for 7 months now. I have eliminated heartburn and healed all of my gastric ulcers.

@terid7996 3 years ago

My great grandmother was 102 years old when she passed away in her sleep; no diseases, no medication and was sharp as a tack! I don't believe diseases are inevitable.

@martinworkens6130 4 years ago

I remember Jack LaLane the 1950s , 60s exercise guru always said “sugar is poison for your body” nobody took him seriously at the time.

@veryberry5138 4 years ago (edited)

The best thing to do is to stop eating all of the time ! Years ago , when I was 198 pounds and sick 😷 with everything , my doctor told me I ate to much . Now I’m 127 pounds nearly 50 and don’t look a day over 28 , with excellent blood work all organic without crazy effort ! ! I eat two meals a day , sometimes , three if I’m really hungry 😋 The bottom line is ….I listen to my body and I only eat when I’m hungry 😋 people are so possessed by food 😩😡

@RGC-u3s 1 year ago

Mark, please avoid interrupting him

@vimalastorey7735 2 years ago

This confirms the yoga teachings that eat the biggest of your meals when the sun is at its higgest. ❤

@carolwong9279 3 years ago

I’m a plant based nephrologist and try to promote diet and lifestyle to my patients. Many have stabilized their kidney function and avoid dialysis. Sadly, many of my colleagues don’t believe in this approach.

@StillMindStrongBody111 3 years ago (edited)

Yes, when we shift back to an ancestral-type lifestyle, meaning less of a garbage that’s being sold as a food because we’re finding more and more that it’s a toxic product, and exercise. Back in the day, we had to work for our food physically and then we were outside all the time!. We were in the extremes, the cold, and the heat, so that makes so much sense! Love this discussion.

When we snap out of the pleasure principle, we find the true pleasure, the true living !!! Health and Vitality. And more focus. Our brains are so much healthier too, which means more power in our senses, and that is be on the five senses! Look around we are having a crisis of the brains in the world right now. Madness appears to be setting in.

Berberine is a great supplement that lowers the effect of carbohydrates on a person’s insulin. It also kills parasites! I believe parasites are also causing a lot of illness and death. Dr. Alan Macdonald proved that in his speech called MS as a paracytosis.

@t.t.8878 3 years ago

My mother had cholesterol near 300 all her life. She ate whatever she wanted, including about a pound of chocolate every week. She never exercised either. Died in her bed age 89.
I think she did very good. ( no medication either)

@winstonbrown347 2 years ago (edited)

I've made it to eating every 2-3 days once. My insomnia is getting better, weight is dropping. I have a home office job, so I set up my desk outside with a walking pad for 15-20 miles five days a week with clesthenics every 30 min and exercise hard on Saturday. Starting to look like a greek god.

@wamut-nt 3 years ago

At 77 and having had to experience being told I only had months to live, during which I went through the saga of grieving in an almost continuous lock-down in Melbourne Australia. which turned out to be a misdiagnosis, i would welcome some discussion on the role of losing fear of death, simply as a part of ‘resetting’ for well-being. Of course the downside of all this is that the people likely to be in a position to benefit and maybe privatise longevity research are the very same, who won’t allow free basic health care for millions of people. Apart from ethical concerns, I don’t think I’m intelligent enough to sort through the issues of ‘suffering and death’ being at the core of what makes us ‘human’, so I’m just left wondering what it might be like to have my body reset from 60 to 30, when we’re told that our brains change as we go… an old mind in hormone driven, young body…traumas and thrills, a new horizon for therapy?

@animishasomayajula4155 2 years ago

My two most fav people(health experts ) in one video!

@RogueCylon 4 years ago

It’s hard to find a reliable source for NMN. Most comes from China, and is suspect. Some folks have lab tested the most popular brands and found them to have no NMN?

@SilverFan21k 3 years ago

Ty Dr. Hyman for having on David Sinclair. ❤ didnt see this video until now

@CelsoClerigo 1 year ago

Thank you Dr David & Dr Mark... bless you..!

@lisengel2498 3 years ago (edited)

My grandmother told me that nearly 60 years ago - and I still like to wake up with the Sun …. And I always like to eat most early in the day and I even experiemted with the last meal at 2 pm - and thats truly a fine Way of having very high Energy ….But it is off rhytm with the most common culture. 🙃🎵💜🎶

@sandraelder1101 4 years ago

So there’s real wisdom in the old saying, “Breakfast like a king, lunch like a prince, dinner like a pauper.”

@MethodosEuzoias 4 years ago

I totally rely on that a patient may know much more about his disease than an expert doctor. I'm 28, have crohn's disease for 13 years and treating it with diet.
If it weren't for crohn's i dont know if i would ever get on board on the marvellous ship of wellness and long living. I think that i might start feeling lucky about my disease because of all the doors to science and biochemistry that it opened for me!
I'm loving it!!