Fasting as a Path to Longevity: The Facts | Lifespan with Dr. David Sinclair - S2, Ep. 2
David Sinclair
158,851 views
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
__________________________________________
In this episode of Lifespan Season 2, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and pioneer in longevity research – explores the science of calorie restriction and fasting, two of the most studied interventions for healthy aging.
Drawing on decades of research, Dr. Sinclair explains how eating less – and eating less often – affects the biology of aging, why our evolutionary past may predispose many of us to weight gain, and what the latest human and animal studies reveal about lifespan, metabolism, and disease risk.
Whether you're interested in longevity, metabolism, or intermittent fasting, this episode provides an evidence-based look at one of the most powerful strategies for supporting health and longevity.
__________________________________________
Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN
○ Withings: Get 10% off smart health devices at https://withings.com/LIFESPAN
__________________________________________
Legal & Medical Disclaimers
The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.
You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.
The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.
Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.
From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.
Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.
The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
20 Comments
Used to exercise, drink coffee, eat breakfast, then walk 4 miles. Last week bought ketones. Now exercise, drink coffee, drink ketone, walk 4 miles (energized) , eat breakfast 2 hours later then before. My girlfriend asked "Did you lose weight?". Not sure since I don't own a scale. Feel better though.
Thank you so much for the history and knowledge!
I FEEL like a YOUNG kid rushing home to watch Nova on Wednesday nights !
Fasting as a Path to Longevity: The Facts | Lifespan with Dr. David Sinclair - S2, Ep. 2
David Sinclair
158,851 views
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
__________________________________________
In this episode of Lifespan Season 2, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and pioneer in longevity research – explores the science of calorie restriction and fasting, two of the most studied interventions for healthy aging.
Drawing on decades of research, Dr. Sinclair explains how eating less – and eating less often – affects the biology of aging, why our evolutionary past may predispose many of us to weight gain, and what the latest human and animal studies reveal about lifespan, metabolism, and disease risk.
Whether you're interested in longevity, metabolism, or intermittent fasting, this episode provides an evidence-based look at one of the most powerful strategies for supporting health and longevity.
__________________________________________
Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN
○ Withings: Get 10% off smart health devices at https://withings.com/LIFESPAN
__________________________________________
Legal & Medical Disclaimers
The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.
You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.
The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.
Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.
From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.
Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.
The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
My name is Maryam Shayesteh, and I live in Pensacola, Florida.
I have watched almost all of your videos, and I have listened to some of them many times.
For more than five years, I have been eating one meal a day. By “one meal,” I mean that I only eat during a 2- to 3-hour window each day. Every morning, I drink plain black coffee, and for the rest of the day, I drink water.
I do not consume anything sweet, and I do not eat carbohydrates. About 99% of the time, my food is only red meat, sometimes with walnuts. The only fruit I eat is blueberries, which I pick in large amounts from a farm and store in my freezer.
I fast for more than 22 hours every day, and from time to time, I also do longer fasts, usually between 3 to 7 days.
I am 47 years old, and I work out at the gym for more than an hour every day, including weight training.
People often tell me that I look more than 15 years younger than my actual age. I also have a very high level of energy.
I believe I may be a good real-life case for studying the lifestyle you are researching.
If there is any way I can help with your scientific research, I would be very happy to do so. I would love to make even a small contribution to the meaningful work you have started.
Your teachings have helped me a lot. They have helped me build strong logical reasons in my mind, which support me in staying consistent with this lifestyle.