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GLP-1 Medications May Do More Than We Thought!

The Loving Diet

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GLP-1s and Inflammation: What the New 2026 Research Review Suggests.

Study in video: Quintana L, Tabaza N, Kurt B, Kahles F. Anti-inflammatory effects of GLP1 RA drugs. The Journal of Clinical Endocrinology & Metabolism. 2026;111:e2076 to e2085. doi:10.1210/clinem/dgag218.

Are GLP-1 medications doing more than supporting weight loss—could they also reduce inflammation directly? In this episode, nutritionist and author Jessica Brown breaks down a July 2026 review in the Journal of Clinical Endocrinology and Metabolism exploring how GLP-1 receptor activation may influence immune cells, inflammatory signaling pathways (including NF-kappa beta), cytokines, and inflammatory biomarkers. She explains the difference between normal inflammation and chronic dysregulated inflammation, why scientists are investigating immunomodulatory effects beyond metabolic improvements, and what remains unknown about how independent these effects are from weight loss and better metabolic health. Jessica also previews a series covering the review’s findings related to cardiovascular disease, autoimmune disease, sepsis, and neurodegenerative diseases.

00:00 GLP-1s and Inflammation
00:26 Why This Research Matters
02:14 The 2026 Review Study
03:26 Inflammation Basics
04:19 Immune Signaling Explained
06:13 GLP-1 and Immunomodulation
07:51 Key Pathways and Cytokines
08:48 Weight Loss vs Direct Effects
10:49 What Comes Next
11:50 Big Takeaways and Wrap Up

20 Comments

@scottlemaitre 4 weeks ago

GLP-1 is not a drug, it is a natural peptide found in the body, engineered yes to last longer, but GLP-1’s natural home is the human body, GLP-1 speaks the human language that sends messages to ALL organs to get them to repair inflammation and defective cells. Naturally GLP-1 only lasts 2 minutes, GIP lasts 4 minutes, engineered to now last 5-7 days. Hail GLP-1/GIP.

@annmarie- 4 weeks ago

It helps my RA with no side effects like biologics have.

@ainsliecollison7986 3 weeks ago

The inflammation and pain that I have had for at least 20 years was gone within hours of using the first injection - way before I started losing any weight. The fluid also cleared from my lungs, feet and ankles within those few hours. This was in January this year. I have stayed on 5 mg and lost 20 kg. Although I will be 80 later this year, I feel at least 10 years younger and now have the desire to live which I did not have last year. Wish I had started it years ago.

@michaelbreen8983 4 weeks ago

October 2024 I was age 64, 6'2" 347 lbs with A1C of 6.8. I had sleep apnea, back, neck, and knee pain. My doctor diagnosed me with diabetes 2 and put me on Mounjaro. I had seen how devastating diabetes can be with family members so decided to get serious. I quit drinking 🍸all alcohol, ate a more healthy diet, and increased fiber intake. While it wasn't always easy today I'm down to 220 lbs a weight I have not seen since high school. Sleep well even on my stomach at times. Wake up after 6-7 hours ready to take on the day. Never tired during the day now. My doctor and Mounjaro gave me my life back!

@DanielHomeImprovement 3 weeks ago

fascinating, this might be the discovery of the decade

@joanneplante7883 2 weeks ago

I hope research can find help for autoimmune in glps 🎉❤

@migispins 4 weeks ago

This medication has put my Fibromyalgia, Chronic Fatigue and eczema all in remission. So much so my Lyrica is now only twice a week, when prior 2as up to 300mg twice daily!!
So not an autoimmune but an inflammatory condition for sure!!
Thank you, looking forward to more on this review.

@kyoung4534 3 weeks ago

I have been on a glp for only roughly months. I had my highCRP checked and it was down to 2.2. I know this is still high it should be less that 1. The miracle is it was around 15.3 last year. I have done it all, keto, carnivore, fasting for days, metformin, berberine. You name i tried it except stating and steroids. My doc suggested them but I refused. This moved the needle like nothing else EVER!

@ZoeyTike 4 weeks ago

Love your videos. I was technically at a “normal” BMI of 24.9 when I started taking tirzepatide 7 months ago. Not only have I been effortlessly maintaining a 22 bmi, my hashimotos antibodies have been halved. It’s miraculous. I’ve tried everything and nothing has moved the needle in this way.

I’ll be on tirzepatide for life or until something better is developed.

@niickjonnas 3 weeks ago

the extra benefits are interesting, but i still wouldn’t treat GLP-1s like they fix everything. i’m more interested in the proven metabolic side, which is why microdose tirz from Aurelius Health Group is still the part that makes the most sense to me

@jacquelinegonzalez888 4 weeks ago

Love your positive research! Thank you! So hopeful🤗🎉

@RsMahmudStudio01 3 weeks ago

I’m a professional video editor and thumbnail designer. Loved The Loving Diet’s insightful breakdown on emerging research regarding GLP-1 medications and chronic inflammation—especially exploring the July 2026 review from the Journal of Clinical Endocrinology and Metabolism on immunomodulation, how GLP-1 receptor activation directly influences immune cell pathways and inflammatory signals (like NF-kappa beta and cytokines) beyond simple weight loss and metabolic improvements, and previewing upcoming findings on cardiovascular, autoimmune, and neurodegenerative conditions. I actually created a custom-made thumbnail specifically for your video to help it stand out and get more clicks. What would be the best or easiest way to send it over to you for review?

@gerrym-cat7119 4 weeks ago

GLP-1 agonists are longevity drugs.

@pjkkmason 3 weeks ago

Retatrutide has changed my life along with other peptides. I have Hashimotos and feel so much better, lost some weight and just overall normal. Eating clean, enough sleep, walking 8000 steps a day, 3x a week of resistance training and trying to have no stress plus glp and peptides has belped immensly. Thanks Jessica! Love your videos!

@TLS31255 3 weeks ago (edited)

So, I have Crohn’s disease. My gastroenterologist informed me that weight loss can help reduce inflammation. Almost two years ago, I had a colonoscopy, and the results showed inflammation in my colon. The gastroenterologist , advised for me to monitor this condition because it could potentially lead to cancer. Although it’s not specifically approved for inflammation, it’s an additional reason why I’m taking it. My lab results have been pretty good so far. I have another colonoscopy scheduled for two months, and I’m hoping that I’m in remission.

@rmcl2525 3 weeks ago

I'm on my 6th week of GLP-1. I have lost about 5 pounds so far. The biggest change I noticed was 50% reduction in joint pain after playing pickleball in the first 2 weeks. Food noise is gone along with desire for booze. This drug is a game changer so far.

@mikepost8965 4 weeks ago

For me, the pain came before the weight gain. My pain is less after a year on Mounjaro, but I still have pain.

@LithiumSix66 4 weeks ago

They lower it. I had labs done

@CristiVladZ 4 weeks ago

do you happen to have the full text of the paper?

@Muh.ArBud011 2 weeks ago

Weight loss drugs sound tempting 😔 but relying on synthetic fixes for life made me hesitate when dealing with menopause fat and fatigue. A lady on a forum recommended the Hormonal Reset Protocol author is (Emma Wells). Followed her gentle system—28 lbs melted off effortlessly, my sleep reset, and my mood stabilized. Now I understand why this is blowing up!