The San Francisco 49ers are back at home for a massive Week 4 matchup against the Denver Broncos.

Brandon Deutsch and Tyler LaRocca break down the 49ers vs. Broncos matchup, the biggest factors that could decide the game, and whether San Francisco can stay undefeated despite injuries continuing to pile up on both sides of the ball.

Can Brock Purdy continue playing at an MVP level against one of the toughest defenses the 49ers have faced this season? What will San Francisco need to do offensively to handle Denver’s defense? And can the 49ers overcome their growing injury concerns and improve to 4-0?

Brandon and Tyler discuss all of that and more in this complete 49ers vs. Broncos Week 4 preview.

🏈 Topics Discussed:
• 49ers vs. Broncos Week 4 preview
• Brock Purdy’s MVP-level start to the season
• How Purdy matches up against Denver’s defense
• The biggest keys to a 49ers victory
• San Francisco’s growing injury concerns
• What will dictate the Broncos vs. 49ers matchup
• Can the 49ers improve to 4-0?

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