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Embryology | Development of Reproductive System

Ninja Nerd

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📚 Premium Notes & Illustrations for Reproductive System Development: https://www.ninjanerd.org/lecture/dev...

Ninja Nerds!
In this embryology lecture, Professor Zach Murphy presents a comprehensive overview of the reproductive system's development, tracing the transformation from indifferent gonads into male or female reproductive organs. The lecture emphasizes the critical timing, signaling pathways, and embryologic structures that govern sexual differentiation.

We begin with the formation of the gonadal ridges from intermediate mesoderm and how the presence or absence of the SRY gene on the Y chromosome initiates testis or ovary development. Zach breaks down the role of testosterone, dihydrotestosterone (DHT), and Müllerian inhibiting substance (MIS) in the differentiation of the Wolffian (mesonephric) ducts into male internal structures and the regression of the Müllerian (paramesonephric) ducts.

In contrast, he explains how—without SRY and with the absence of MIS—the Müllerian ducts persist to form the fallopian tubes, uterus, and upper vagina, while the Wolffian ducts regress. The lecture also covers the development of external genitalia, guided by hormonal signaling, and the formation of structures like the penis, scrotum, clitoris, and labia.

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20 Comments

@kerianjohnson2972 5 years ago

PROTECT THIS MAN AT ALL COST!! Thank you Zach! You the G.O.A.T 🐐

@isabelladloa 1 year ago

i feel like i love you 😭

@muqaddasbibi367 1 year ago

Anyone watching this legend in 2025 ❤

@penni0205 4 years ago

I literally owe you my whole degree, Thank you a million times!!

@bsoomy2010 2 years ago

Brother is a life savior. Embryology for me is one of the most difficult subjects but with your videos I keep breezing through the exams

@dorcasb2194 5 years ago

Please do a video series on how to read and interpret X-rays and other radiographs. Thanks

@RashmiKamath1201 5 years ago

What a beautiful way of explaining! The universe needs more teachers like you <3

@rwanelnkhal3681 10 days ago

the fact that he didn`t even go to med school is impressive what a genius man rlly

@wardahsaleem9395 3 years ago

I haven't touched these topics during the whole year & I feel like he's that friend trying to rapidly teach me all of it a night before the exam 🥺

@abdulrahamangamal1966 5 years ago (edited)

man I am glad me and you are living in the same era

@Dreamland-l3f 5 years ago

I was prayin you’d upload this before my exam and you actually did! Thank you man u da beeeest

@charlesakhimienmhonan2175 4 years ago (edited)

Hello Zach, This is a very good one. Although, there are terms and areas not mentioned, which includes:
1) Indifferent Gonads, which was explained but the term is important.
2) The periods of development. The indifferent gonads starts at 4th week ; while their differentiation to the different sexes start from 7th week for male testes and 12th week for female ovaries.
3) Paramesonephric duct fuse at the distal end to form UTEROVAGINAL PRIMORDIUM that give rise to the UTERUS and the UPPER 1/3rd of VAGINA.
4) The UROGENITAL SINUS forms amongst other structures the LOWER 273rd of VAGINA.
5) Every organs epithelial or mucosa layers and glands are formed by endodermal cells; the mesenchymal cells form the connective tissues and smooth muscles.
6) It is 5-ALPHA REDUCTASE 2 that converts testosterone to DHT
7) Primary sex cords form the rete testes , while cortical cords or secondary sex cords of ovaries form the primordial follicular cells They are derived from surrounding mesothelium.
Thank you.

@jacobjamescabrera2651 4 years ago

Having our repro unit exam in a week and this just helped clear up what Langman overcomplicates. God Bless you always, Doc! Praying for your health and thank you for teaching us these stuff and making them digestible for us

@amaranthines. 4 years ago

I'm kinda bitter this isn't available during my medschool, haha. I had too much trouble consolidating different textbooks with this kind of understanding as a goal but I didn't even come close to part of what he has just presented. Never too late though. Lifelong learning they say. Thank you so much doc!

@nachiketarai5872 5 years ago

I literally don’t know why this video has got such less amount of views.. this was amazing 🤩

@Kaan-rs6hi 1 year ago

Man you don’t know how much I love and respect you
U saved my educational career

@mohamedfaiz3377 5 years ago (edited)

I don't think this video came out on valentines Day by coincidence.
And lovely job, huge fan ✌

@Mooonnn_09 2 weeks ago

Thank you so much sir !❤

@yerlihernandez4903 5 years ago

You guys are stars, the work you do, the beautiful intentions you have, and all this free education you provide us, it just AMAZING. For people like you is that I still believe in the goodness of humanity! THANK YOU, THANK YOU, I can't say enough times! :) :)