Could DMT temporarily transform the human perceptual interface, making conscious agents that are normally invisible to us perceivable?
Donald Hoffman and Andrew Gallimore examine this extraordinary question through neuroscience, mathematics, and the possibility that what we perceive is only a limited interface with a deeper reality, developing a framework that could be tested empirically.
This conversation marks the first public partnership of the Trace Institute Collaboration Program, developed with Noonautics and moderated by Charles Yokoyama.
Subscribe to the Trace Institute for new research, films, and conversations exploring consciousness and the fundamental nature of reality.
EXPLORE THE RESEARCH
Read the paper and explore the Trace × Noonautics collaboration: https://traceinstitute.org/collaborat...
Visit the Trace Institute: https://traceinstitute.org/
The Trace Institute is a non-profit research organization with a mission to build a science of
reality based on mathematical modeling of conscious observers. Founder and Scientific
Director Donald D. Hoffman is Professor Emeritus at the University of California-Irvine, who
developed the interface theory of perception, conscious agent theory, and the trace logic of
conscious realism, among the first unified, observer-centered models of nature.
Learn more about Noonautics: https://noonautics.org/
Noonautics is a 501(c)(3) non-profit research organization supporting public-facing research
into the structure of the mind and the nature of non-ordinary experience. Director Andrew R.
Gallimore is a pioneer of DMT research and co-inventor of the DMT extended state
pharmacokinetic model, termed DMTx, with Dr. Rick Strassman. He is based at the Okinawa
Institute of Science & Technology
ABOUT THE CONVERSATION
What if the world we perceive is not reality itself, but a species-specific interface shaped by evolution?
Donald Hoffman’s theory of conscious realism proposes that conscious agents and their interactions are fundamental, while spacetime and physical objects are representations within a perceptual interface.
Andrew Gallimore’s research asks whether DMT can temporarily transform that interface, allowing human observers to experience structures or conscious agents that are ordinarily inaccessible.
Together with mathematician Niffe Hermansson, Hoffman and Gallimore have developed a formal framework intended to generate predictions that can be investigated and potentially falsified.
Recorded on June 13, 2026, at The Lighthouse Campus in Los Angeles.
FEATURING
Donald Hoffman
Cognitive scientist, co-founder of the Trace Institute, and Professor Emeritus at the University of California, Irvine
Andrew Gallimore
Neurobiologist, pharmacologist, author, and founder of Noonautics
Moderated by Charles Yokoyama
Trace Institute researcher and former Senior Scientific Editor of Neuron
#DonaldHoffman #AndrewGallimore #Reality #DMT #Philosophy #Neuroscience #Psychedelics #Science #TraceInstitute #TracesOfTheOther #Consciousness
Could DMT temporarily transform the human perceptual interface, making conscious agents that are normally invisible to us perceivable?
Donald Hoffman and Andrew Gallimore examine this extraordinary question through neuroscience, mathematics, and the possibility that what we perceive is only a limited interface with a deeper reality, developing a framework that could be tested empirically.
This conversation marks the first public partnership of the Trace Institute Collaboration Program, developed with Noonautics and moderated by Charles Yokoyama.
Subscribe to the Trace Institute for new research, films, and conversations exploring consciousness and the fundamental nature of reality.
EXPLORE THE RESEARCH
Read the paper and explore the Trace × Noonautics collaboration: https://traceinstitute.org/collaborat...
Visit the Trace Institute: https://traceinstitute.org/
The Trace Institute is a non-profit research organization with a mission to build a science of
reality based on mathematical modeling of conscious observers. Founder and Scientific
Director Donald D. Hoffman is Professor Emeritus at the University of California-Irvine, who
developed the interface theory of perception, conscious agent theory, and the trace logic of
conscious realism, among the first unified, observer-centered models of nature.
Learn more about Noonautics: https://noonautics.org/
Noonautics is a 501(c)(3) non-profit research organization supporting public-facing research
into the structure of the mind and the nature of non-ordinary experience. Director Andrew R.
Gallimore is a pioneer of DMT research and co-inventor of the DMT extended state
pharmacokinetic model, termed DMTx, with Dr. Rick Strassman. He is based at the Okinawa
Institute of Science & Technology
ABOUT THE CONVERSATION
What if the world we perceive is not reality itself, but a species-specific interface shaped by evolution?
Donald Hoffman’s theory of conscious realism proposes that conscious agents and their interactions are fundamental, while spacetime and physical objects are representations within a perceptual interface.
Andrew Gallimore’s research asks whether DMT can temporarily transform that interface, allowing human observers to experience structures or conscious agents that are ordinarily inaccessible.
Together with mathematician Niffe Hermansson, Hoffman and Gallimore have developed a formal framework intended to generate predictions that can be investigated and potentially falsified.
Recorded on June 13, 2026, at The Lighthouse Campus in Los Angeles.
FEATURING
Donald Hoffman
Cognitive scientist, co-founder of the Trace Institute, and Professor Emeritus at the University of California, Irvine
Andrew Gallimore
Neurobiologist, pharmacologist, author, and founder of Noonautics
Moderated by Charles Yokoyama
Trace Institute researcher and former Senior Scientific Editor of Neuron
#DonaldHoffman #AndrewGallimore #Reality #DMT #Philosophy #Neuroscience #Psychedelics #Science #TraceInstitute #TracesOfTheOther #Consciousness