Tom (Scott Speedman) and Dan (James Marsden) meet in a bar and then proceed to Tom's apartment together. While there, Dan realized that he had been in that same apartment before.

Five years earlier, Dan and Tom had one night stand there. According to Tom, that encounter with Dan was his first and only homosexual experience.

Some years later, Tom's wife is found to be HIV positive. Despondent after receiving this diagnosis from her doctor, Tom's wife drives through a red light traffic and is killed in an ensuing collision. Subsequent to these events, medical tests reveal that Tom is also HIV positive. Tom blames himself for passing HIV on to his wife and, in turn, he blames Dan for passing the virus on to him. Reasoning that Dan, ultimately, is to blame for his wife's death, Tom devises a plan to exact revenge.

He holds Dan hostage, keeping him bound and gagged to a chair in his apartment. He draws blood from Dan in order to conduct a test to determine Dan's HIV status. If Dan's test results are positive for HIV, Tom vows to kill Dan. If the results are negative, Tom agrees to release Dan unharmed.