Approach to bleeding disorders - causes, pathophysiology and investigations
Armando Hasudungan
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Bleeding disorder can be either due to a problem in primary hemostasis or secondary hemostasis. Primary hemostasis related bleeding disorder are due to problems with platelets - either reduced production, increased consumption or increased destruction. Secondary hemostasis related bleeding disorders are caused by problems with the clotting factors - either a deficiency or presence of an inhibitor against the clotting factor. aPTT and PT are investigations used to see how effective the clotting factors are at forming a clot. A prolonged aPTT or PT means that the person has a tendency to bleed.
#bleedingdisorders #hematology #coagulopathies #blooddisorders #medicaleducation
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This content is provided for educational purposes only and is not intended as medical advice, diagnosis, or treatment. It should not be used as a substitute for professional clinical judgment or consultation with a qualified healthcare professional. Always seek the advice of your physician or other qualified health provider regarding any medical condition.
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20 Comments
A worrying aspect is that some defects can go unnoticed until they undergo a hemostatic stress situation, such as surgery or trauma. This highlights the importance of prior evaluation in patients with a family history or risk factors. On the other hand, conditions like hemophilia or thrombocytopenia can lead to serious complications, including joint or intracranial hemorrhages, which are life-threatening.
Furthermore, the clinical relevance of bleeding not only depends on the volume lost but also on its location. A small hemorrhage in the skin may be harmless, but the same amount of blood in the brain can be lethal. This underscores the need for timely diagnosis and management to avoid irreversible consequences.
Also, it's important to consider liver disease and vitamin K deficiency as potential causes of prolonged PT and aPTT, since the liver is responsible for synthesizing most clotting factors, and vitamin K is essential for factors II, VII, IX, and X. In cases of suspected vitamin K deficiency, we can check levels of protein induced by vitamin K absence (PIVKA-II) or assess response to vitamin K administration.
Thanks for this video, super useful for understanding coagulation and the different causes of bleeding disorders!
All your vedios depict wit and wisdom.
Which country are u from.
God bless you...great great job π·ππ€²
Approach to bleeding disorders - causes, pathophysiology and investigations
Armando Hasudungan
285,746 views
Join the Community: https://armandoh.org/sp/beta-member/
Bleeding disorder can be either due to a problem in primary hemostasis or secondary hemostasis. Primary hemostasis related bleeding disorder are due to problems with platelets - either reduced production, increased consumption or increased destruction. Secondary hemostasis related bleeding disorders are caused by problems with the clotting factors - either a deficiency or presence of an inhibitor against the clotting factor. aPTT and PT are investigations used to see how effective the clotting factors are at forming a clot. A prolonged aPTT or PT means that the person has a tendency to bleed.
#bleedingdisorders #hematology #coagulopathies #blooddisorders #medicaleducation
Social media:
π· Instagram: Instagram: armandohasudungan
π: https://x.com/armandohasudung
πFacebook: Facebook: ArmandoHasudungan
Our mission:
We turn healthcare education from consumption into collaboration.
Medical disclaimer:
This content is provided for educational purposes only and is not intended as medical advice, diagnosis, or treatment. It should not be used as a substitute for professional clinical judgment or consultation with a qualified healthcare professional. Always seek the advice of your physician or other qualified health provider regarding any medical condition.
Β© Visualising Medicine. All rights reserved.