OpenTube

Are GLP1’s For Everyone? Which One Is Right For You?

Talking With Docs

205,736 views

📩 Contact us: talkingwithdocs@gmail.com

GLP-1 medications have become some of the most talked-about treatments for weight loss and type 2 diabetes, but there is also a lot of confusion around how they work, who should take them, and whether they are safe.

In this episode of Talking With Docs, Dr. Brad Weening and Dr. Paul Zalzal are joined by endocrinologist Dr. Ihab Kandil to discuss GLP-1 receptor agonists, how these medications work, and what patients should know before considering treatment.

The doctors explain what GLP-1 is, how it naturally regulates appetite and blood sugar, and how medications like semaglutide and tirzepatide mimic these effects. They also break down the differences between Ozempic, Wegovy, Mounjaro, and Zepbound, why they are prescribed for different conditions, and what makes newer medications like retatrutide so exciting.

Importantly, they discuss the potential side effects of GLP-1 medications, including nausea, constipation, diarrhea, heartburn, and the rare risk of pancreatitis. They also explain why some muscle loss can occur with significant weight loss, how adequate protein intake and resistance training can help preserve lean muscle, and what patients should know before stopping these medications due to the risk of weight regain.

The conversation also explores who may benefit from GLP-1 therapy, why lifestyle changes remain the foundation of treatment, and why these medications should only be used under proper medical supervision.

You'll learn:
• What GLP-1 is and how it works in the body
• What GLP-1 receptor agonists are
• How GLP-1 medications reduce appetite and improve blood sugar
• The differences between Ozempic, Wegovy, Mounjaro, and Zepbound
• How semaglutide differs from tirzepatide
• What retatrutide is and why researchers are excited about it
• How much weight people may lose on GLP-1 medications
• Common side effects and how they can often be managed
• The rare but important risks associated with GLP-1 therapy
• Why muscle loss can occur during weight loss
• How protein intake and resistance training help preserve muscle
• Why stopping GLP-1 medications may lead to weight regain
• Why GLP-1 therapy should be combined with healthy lifestyle changes
• Who may be an appropriate candidate for these medications
• Why buying GLP-1 medications from unregulated sources can be risky

If you're considering Ozempic, Wegovy, Mounjaro, Zepbound, or simply want to better understand how GLP-1 medications work, this episode provides a balanced, evidence-based discussion with an endocrinologist.

🎧 Listen on Your Favourite Platforms:
Spotify:
https://open.spotify.com/show/3OFxEji...
Apple Podcast:
https://podcasts.apple.com/ca/podcast...
YouTube Music:
• TWD Podcast

👕 Shop Our MERCH:
https://www.spreadshirt.ca/shop/user/...
❤️ Support Oakville Hospital:
https://donate.oakvillehospitalfounda...

📱 Follow Us:
TikTok:
TikTok: talkingwithdocs
Instagram:
https://www.instagram.com/talkingwith...
Facebook:
https://www.facebook.com/profile.php?...

🛑 DISCLAIMER:
This content is for educational purposes only and is not a substitute for professional medical advice. GLP-1 medications should only be used after proper medical evaluation and discussion with a qualified healthcare provider. Do not start, stop, or change any medication without speaking with your healthcare provider. Full disclaimer at talkingwithdocs.com.

#GLP1 #Ozempic #Wegovy #Mounjaro #Zepbound #Semaglutide #Tirzepatide #WeightLoss #Type2Diabetes #Obesity #Endocrinology #HealthyAging #HealthResearch #TalkingWithDocs

20 Comments

@vxinos 3 months ago

After talking to my GP in February about my chronic pain and struggles to lose weight as a type 1 diabetic on insulin and no matter how hard I try I couldn’t lose any weight. She did some bloodwork and Discovered I was insulin resistant and had fatty liver disease. Basically I showed both signs pf type 1 and type 2 diabetes. She suggested I try Zepbound. From the very first starter dose my chronic pain is soooo much better My total insulin needed to keep me in range dropped by half and I’m finally losing weight at a healthy rate of 2 to 3 lbs a month. My constant hunger is gone! Completely gone! And I finally feel free. I know I will be on these shots longterm and I’m ok with this knowing that my health and quality of life has drastically improved

@Keke91654 2 months ago

I’ve been on Zep since October ‘25. Still on the lowest dose of 2.5. Losing an average of about 1 lb a week. Diet is key for avoiding side effects. Strength training is key for retaining muscle. Many go on these meds with no guidance. Doctors need to be more helpful when they prescribe. Thanks for this awesome information.

@karenuhrich9683 3 months ago

I have lipedema in my legs and went on a GLP1 to see if it would help with the pain and inflammation, which it has. I didn't have much weight to lose, so that for me was just a secondary bonus. I am grateful my doctor listened to me and prescribed it.

@joanoconnell2956 3 months ago

Excellent discussion with Dr Kandil! ❤ Thanks!

@mhartman69 2 months ago

66 years old, down 50 pounds in 50 weeks on tirzepatide at 15 mg. At my goal weight so I’m going to reduce to 5 mg per week. This was really my goal a year ago, and I’m so excited to have made the decision to get healthy! This has been so easy, I feel like I’m cheating. I’m in the gym three times a week to keep muscle mass up. My doctor has been tracking my progress. Mild nausea day two or three after the shot but other than that, food noise is way down, and mild constipation is manageable.

After trying for 20 years to lose this weight I am very grateful we have this option today👏

@trekuhl3966 3 months ago (edited)

As a 64 year old man, I’ve thought about GLP-1’s following my diagnosis with Type 2 and High Blood Pressure. For me, the old-fashioned way diet and exercise, is working for me. I’ve lost weight, down to 245 from 315, the biggest change is a reduction in my body fat from 32 to 23 1/2%. As I continue, this journey, to get down to 210 lbs (I’m 6’-3”) my lean muscle and body fat continue to ebb and flow. I am at the gym 5 to 6 days a week, concentrating on resistance training and lifting while working on zone 4 cardio, yoga and mobility.

Occasionally, I think about GLP-1’s however what I’m achieving through diet and exercise continues to work for me. I may be the exception as diet and exercise to lose weight, while getting stronger is unusual for someone my age. Plus, my mobility and range of motion has improved as well.

My journey continues! Thank You Doc’s.

@ginnal8071 2 months ago

I wish you covered GLP-1 and how it may benefit cardiovascular health.

@victoriajohnson3034 3 months ago

Funny that no one mentions victoza. It was the first Glp1 and still prescribed today.

@grantmelocik1703 3 months ago

My main interest is the impact on heart arrythmia and reduced dementia. I am slightly overweight I would welcome the weight loss, however, the early impressive positive results on arrythmia (a huge problem for me with 7 ablations) and dementia (at 74 and still healthy I fear this age related issue more than anything) are what I want to hear more about.

@N14158TL 3 months ago

Spot on. It never occured to me in all my years, that hunger signals can be dramatically different for different people. I owe a lot of apologies due to my ignorance. Great segment, glad to see retatrutide being discussed.

@cpraed6025 3 months ago

Why don’t any of the doctors refer to the GLP-1 I use, which is Dulaglutide, brand named Trulicity? I’ve taken it for type 2 diabetes for 6 years, had little to no side efforts, other than weight loss. It’s just never mentioned. It’s an Eli Lilly product, like Mounjaro and Zepbound, but a different GLP-1.

@christineperkins9004 3 months ago

Outstanding video: the questions (some I wouldn't have even thought to ask), the answers, the science, the advice. A+.

@JoRod803HP 3 months ago

Thanks for this great info. I have been considering asking my endo doctor about putting me on a GLP since I have obesity and Type 2 diabetes. Now that I am better informed after watching your video, I can discuss it with my doctor.

@NanCot-w2y 3 months ago

What a great show today. Really enjoyed all of you and your guest was amazing.

@LifeWithGaryAndSherry 3 months ago

The biggest reason I watch you two is because of your professional knowledge and input. The second reason (and probably ties with the first) is your humor! Another reason is just now, when you went to bat for folks on this medication. Thank you! Thank you. Love learning from you all! ~Sherry

@bethhennesseymacdonald3243 2 months ago

I have psoriatic arthritis and autoimmune nutrupenia. On steriod type meds. GLP-1 helped me lose weight VERY slowly. In Australia, weight loss is not public funded. Took me 1 year to lose 12kg or 26 lbs. Very expensive exercise when most people lose same amount in 3-4 months. Went off and gained all back

@danondler8808 3 months ago

This was a great video. Very well presented and clear. Thank you, Dr. Zalzal, Dr. Weening and your guest, Dr. Kandil. This has been the best an thorough explanation I have heard.

@joshfields22 3 months ago (edited)

Im on Week 9/10 of taking Mounjaro myself. My starting weight was 398. Im diabetic. I've struggled for so long with food noise and trying everything under the sun that I could try to get my weight under control. Im not lazy, in fact I love working out.

This medicine has changed my life! From the 2nd day I was on this medication, my food noise is completely gone. It was terrifying honestly. Its like someone turned off a loud speaker that was sitting right by my ear. Its given me mental clarity, I'm able to stick to a healthy calorie deficit and have no cravings for any fried/unhealthy foods this entire time (and Im someone who has always loved pizza and fried wings...have had neither in over 2 months). I've also been able to avoid regular soda (I do still enjoy the zero sugar version, 2 or so a day) and drink a lot of water. Im happily down 30+ pounds. Have my next doctor visit next week to see how my bloodwork looks after being on this. Im so excited for the future ahead for the first time in I can't tell you how long.

@laurielatour2862 3 months ago

Wish you had discussed eye problems possibly caused by the meds. I've heard reports even of blindness. True or not?

@moxiepops8457 2 months ago

I started a compounded Trizipatide in March. It has been a miracle for me. I’m losing weight but more importantly I don’t drink alcohol. It has taken away the desire to drink. I say this has a high functioning alcoholic.

I’m down 41 pounds and hope to loose another 40.

As of right now, this is a life long meditation for me. 🙏