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Estradiol, Testosterone, and Bone Density: What the Data Really Shows

The Dr Doug Show | Longevity through Bone Health

11,961 views

In this video, Dr. Doug breaks down the research on estradiol levels and how hormone therapy can influence bone density. He reviews clinical data comparing different estradiol dosing strategies and explains why hormone needs vary from woman to woman. The discussion also explores whether adding testosterone provides additional benefit for bone health. Most importantly, he highlights why optimizing hormones must be individualized rather than using a one-size-fits-all approach.

Study Links
https://pubmed.ncbi.nlm.nih.gov/10321...
https://pubmed.ncbi.nlm.nih.gov/24905...

🔗 Explore Dr. Doug’s Bone Health Resources
Register for the free bone health masterclass, learn more about The OsteoCollective, and find additional ways to connect with Dr. Doug: https://drdouglucas.com/start-here

#osteoporosis
#exercise
#healthspan

Watch and Enjoy! Dr. Doug Lucas Key Moments in this Episode
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Chapters

00:00 The Estradiol Level Question for Bone Health
00:42 Why One Hormone Dose Doesn’t Work for Everyone
02:10 Estradiol Patch Study Most People Misinterpret
03:50 New Study: Can Hormones Restore Bone Density?
06:30 What Happened to Bone Density Over 3 Years
09:00 Why Hip and Spine Respond Differently
11:55 Does Testosterone Improve Bone Density in Women?
14:30 Why the Testosterone Results Are Misleading
17:55 Bone Loss Isn’t Just a Hormone Problem
19:05 Dr. Doug’s Approach to Optimizing Hormones for Bone Health
21:00 The Real Takeaway: Bone Health Must Be Individualized

20 Comments

@New-York-Attitude 5 days ago

I love how clear and informative your videos are! And your new approach to visualizing data works so well. Thank you.

@jenniferaddison9889 6 months ago

I started HRT gel 2 pumps at .75 2 years ago and testosterone cream 1 percent.I was more than 10 years post menopause.
I’ve just had my latest Dexter scan and I have a 10.5 increase in my spine and 4.3 in my hip. My Dr said if it continues it’s likely I’ll be out of the osteopenia range by my next scan due in 2 years. I do weights and jumping and have improved my diet and take Adva Cal which has calcium K2,D3, magnesium Boran and other supporting minerals and follow a strict protein forward diet, which I’ve been doing for years however it is the HRT which I believe has helped the most.

@Dahnoie 6 months ago

I'm a 63 yo woman, I hit menopause late, had a full hysterectomy 2 years ago, had small amounts of hormone replacement for a few years before the hysterectomy. After that I found full and optimal replacement through a specialty clinic. I've been on PET HRT at optimal levels (blood levels consistent with women in their 20s) for about 1 1/2 years. I've also prioritized protein and real fats for 15 years or more. I had a DEXA a few days ago and the technician wouldn't tell me anything but I peaked around her and saw part of my results, most said "Normal". I have a bad hip from a childhood issue and that showed osteopenia which I knew already. I was relieved about the other normal readings which I believe is quite unusual in a woman my age.

@PiaNoLuverr 6 months ago

This channel is GOLD

@nicolemerz1731 6 months ago

Great info, Dr Doug! 💪
I love your critical scientific analyses of research 🙏
Thank you so so much from Germany 🙏💕♀️

@patriciajump9511 6 months ago (edited)

Awesome!!! The way you explain studies is a powerful tutorial that helps people understand and look into studies so they can advocate for themselves. THANK YOU! Having no training in examining studies is a real handicap. (P.S. I personally believed the WHI was wrong as soon as they released the data, based just on my nursing classes in statistics, classes about the physical changes in women as they age, and classes about the relevant diseases and conditions (the comorbidities). They did not competently analyze the data. It was so shocking to me. I was loud about it whenever I got a chance. The WHI "buried" so much data! Population study results do not apply to every single person in a study, especially when it comes to women's hormones.)

@westcoastswingmusic 6 months ago

You are our hero Dr. Doug Lucas! Thank you so much for the lifesaving information you share with us all! 🎉❤🎉

@beautyandbonepath 6 months ago

Great timing for me on this video. Looking at labs this morning after changing from injections to patch. Will need to reevaluate the plan again!

@louisecashd.c.3901 6 months ago

Very helpful. Thanks 😊

@ejsoulsista 6 months ago

Hyped! Excellent information! Many thanks ❤

@SerenidadEnJesus 6 months ago

Thank Dr Lucas for come every tome with lot of info that educate and help us so much. God bless you always.

@asr9217 6 months ago

I suspect genetics plays apart in how we respond to HRT ...my first go also as POI was 7.5%increase in spine and 1.8%increase in hip on .1mg patch. Recently restarted 15yrs out (whi !) on low dose patch and whilst not due dexa yet , after 6 months REMS already shows 4%increase in both and FSH is down ...so guess I'm a good responder ...

@kw6692 6 months ago

I use 2 pumps of Evamist and 100 mg progesterone. I am 55. My DEXA was low normal at 44! I hope this helps. Will check DEXA in a few months.

@LVLADY58 6 months ago

i am 67. i am 25 years post menopause. i just signed up with a tele-med service & have my labs scheduled for march 25th. i had no problems at all until 2025. now i have no energy, motivation or sex drive. i went with tele health online because i could get nothing from my doctor. he told me that he would not prescribe me bhrt even tho my estrodiaol was a 5 on a scale of 0-54, and the reason was because i refused a mammogram. i am hoping that i will get relief from everything that ails me now, including hip pain & leg pain. why would doctors not give me what i am in need of? that really pissed me off. ok rant over.

@sugaree71 6 months ago (edited)

What about DHEA? I take a low sublingual compounded dose in addition to an estrogen patch.

@RRetreat 6 months ago

I am ten years post menopause and started the patch last Sunday. By yesterday I was in such severe lower back pain that I took the patch off. Ugh. I’ll need to rethink this.

@VonnieHendrex-gx8oc 6 months ago

Dr Doug, What do you think about drinking super humic minerals for osteoporosis?

@crystal7245 6 months ago

Would be great f you could do an episode of the biote HRT pellet. I get both testosterone and estrogen. I also take DIM SGS+ as well as progesterone at night. I take other supplements as well. Would like to hear your thoughts. I’m have found it to be very effective also great because I have a toddler at home.

@nahidzarei6924 3 weeks ago

I’m 59 years old and was recently I diagnosed with osteoporosis. I started taking alendronate tablets 2 months ago, and recently my GP said that iHRT it could help my bones .so I started hrt a month ago and I was wondering whether I need to use testosterone as well or not?