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A Mitochondrial Cocktail to Restore Your Cellular Health | Dr Mark Tarnopolsky Interview

Modern Healthspan

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Here we talk with Professor Mark Tarnopolsky from McMaster University about mitochondria, what goes wrong with them in aging and how to he has used a multi-supplement approach to improve their function in aging and in case of disease.
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⏲️Chapters
00:00 Dr Tarnopolosky's research
03:45 Mitochondria
08:00 Mitochondria & aging
10:00 Checking you mito function
15:20 BiOptimizers
16:40 Mitochondria movement
20:00 Is it aging or mitochondria?
24:30 Exercise & mitochondrial aging
28:40 Mitochondrial cocktail
41:00 Obesity cocktail
46:50 Common deficiencies
51:50 Urolithin A
54:30 Mito dysfunction & sarcopenia
57:00 Supplement for muscle growth
1:04:00 Further information

🌐Links in this video
Dr Tarnopolsky's nutrition shop. I think ships to US & Canada only
https://stayabovenutrition.ca/
A selection of Dr Tarnopolsky's papers, including the trials he discussed in the interview
Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders
https://pubmed.ncbi.nlm.nih.gov/17080...
Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults
https://pubmed.ncbi.nlm.nih.gov/17912...
Novel Multi-Ingredient Supplement Facilitates Weight Loss and Improves Body Composition in Overweight and Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
https://pubmed.ncbi.nlm.nih.gov/37686...
A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly
https://pubmed.ncbi.nlm.nih.gov/32785...
A Multi-Ingredient Nutritional Supplement in Combination With Resistance Exercise and High-Intensity Interval Training Improves Cognitive Function and Increases N-3 Index in Healthy Older Men: A Randomized Controlled Trial
https://pubmed.ncbi.nlm.nih.gov/31143...
Lifelong aerobic exercise protects against inflammaging and cancer
https://pubmed.ncbi.nlm.nih.gov/30682...

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#mitochondria #creatine #rejuvenation

20 Comments

@ModernHealthspan Creator 1 year ago (edited) Pinned

BiOptimizers Magnesium Breakthrough 10% with code Modern10 https://bioptimizers.com/modern. This video brought to you by BiOptimizers.
If you would like to support our channel please consider joining our patreon https://patreon.com/ModernHealthspan
Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)
Renue By Science 10% discount code MHS: https://tinyurl.com/37ahmr7d
Wellness Extract 10% discount Code MODERNWE Geranylgeraniol Essential http://wellnessextract.com/RICHARDWE Delta Gold Vit E
Pure Clean Performance 15% code MODERNHEALTH15 Pyre Clean Beets https://tinyurl.com/bdfhfanw
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OmegaQuant 5% discount Code MODERN https://omegaquant.com/shop/
Bulletproof 15% off code: HEALTHSPAN15: https://tinyurl.com/4npjk5vp Omega-3 Krill Oil https://bulletproof.fdf2.net/xkdxmy
Pendulum Akkermansia pendulumtherapeutics.sjv.io/baoQVg Metabolic Daily https://pendulumtherapeutics.sjv.io/NkqE0q
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OneSkin 15% Discount: Code MODERN https://tinyurl.com/3t6tevj8 OS-01 Face Topical Supplement https://tinyurl.com/29c8wrr2
☕If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan

@oldflute 1 year ago

At 38:00, you mention alpha lipoic acid. I am retired now in my 80s, but I taught and practiced Endocrinology 40 years. During the last 12 years I was in private practice, I had all my diabetic patients on daily oral alpha-lipoic acid (only 50-200 mg), CoQ10 if on a statin, and a mix of alpha and gamma tocopherol (vitamins E).
NONE showed any new development of or progression of neuropathy or retinopathy, and one patient over a period of 6 years regained touch and vibration sensation in her feet, which had developed the Charcot deformity from previously dense neuropathy.
Two conclusions:
1. The official ADA guidelines say ALA "may be helpful" in neuropathy. I say it is an essential nutrient for every patient with diabetes.
2. Even severe diabetic peripheral neuropathy is potentially reversible.

@oldflute 1 year ago

Sun exposure is a two way street.
The UV portion of the solar spectrum damages DNA and mitochondria in the skin. The near infrared portion of the solar spectrum is beneficial to mitochondria, both in the skin and the tissues below, because the longer wavelength infrared light (not visible) penetrates a few inches. Infrared exposure is known to increase free radical scavengers in mitochondria: cytochrome C oxidase, glutathione, and melatonin (a more recent discovery).
You can increase the ratio of infrared to UV that reaches the skin in two ways: 1. Wear light clothing that will block UV but not infrared, or 2. Get the exposure near dawn or sunset when the atmosphere filters out much of the UV, but little infrared. You can also get lamps that generate red and infrared, but no UV.

@danevans2397 1 year ago

Listened twice through. As a US pharmacist I endorse every word spoken and theory proposed. I have been taking every supplement mentioned since 2020 and have staved off death despite having stage 3 CKD, 85% of my pancreas digested by a cyst, hyperHOMOCYSTEINemia, and sarcopenia when in 2020 my eating habits changed triggering a 140# loss of weight. I am on disability for they aforementioned disease state plus others including arthritic ankles from a birth defect (bilateral club-foot) poorly explained to my mother in 1969.)
I'd love to lend my insights to nutraceutacle approaches to healing. I've studied mitochondria in depth for the last 4 years and know the subject better than when I graduated from pharmacy school at University. I want to help people heal and doctors to adopt a more erudite approach to patients' lives.
My best abilities are my availability and abstract thinking in a desire for purpose in my life.

@smileman9174 1 year ago

I watch and have listened to thousands of YouTube health videos over the last 3 years. I stumbled on this channel. This was an outstanding interview filled with great information and knowledge from a doctor who's not trying to sell anything! Very hard to find such interviews. I thank both of you very much and I'm going to search for more videos from both of you and subscribe.

@Schu2505 1 year ago

I love Life Extension's Mitochondrial Energy Optimizer with PQQ. I just take one (4 is a serving) to get through the last hour of my shift and arrive home ready to go.

@ScottChristensenabc 1 year ago

Excellent interview…both interviewee and interviewer! Thanks, Richard

@ccamire 1 year ago

Richard, always good and professional content

@chrisf6421 1 year ago

So..the mitochondria cocktail is simply creatine, Vitamin E, ALA, COQ10?

@Daissweetest 1 year ago

B1 deficiency is a big one, I have more energy with b1 hcl.

@markusantonious8192 1 year ago

A shout out here to Prof. Emeritus C. D. Rollo, also of McMaster U.....whose work antedates the good Prof here by two decades or so, and whose work on multiple nutritional supplement stacks demonstrated dramatic amelioration of aging in animal studies....including total abolishment of cognitive decline, resistance to radiation, extension of maximal lifespan, very significant lowering of mitochondrial oxidative stress etc.

@oreoandoz7723 1 year ago (edited)

Excellent, as always. Truly what YouTube SHOULD be - education on issues that matter. Thank you!

@REDLIGHTGLASSESonthischannel 1 year ago

amazing chat, thank you, both. Got 2/3 way through, will come back to finish. 👍👍

@John-kd1bf 1 year ago

It feels like if you were to interview 100 health researchers, 50 would say Urolithin A was not beneficial and 50 would say it’s the eighth wonder of the world.

@volkstouareg5620 1 year ago

Great interview!

@geoattoronto 1 year ago

Creatine, coQ10, aiphalipoic acid, vitamin E, trim 7, vitamin D, B12,

@grainiac7824 1 year ago

There is zero proof for a 6 billion years old world so i don't see any point in guessing how we have the system we have. I just love learning about our wonderfully made bodies!!

@GodfreyMann 1 year ago

Richard, you’re a busy bi - you kip miting so many interesting scientists who highlight the nids for educating us on meetochondria…kip up the great work!

@barbaralopez265 1 year ago

Thamk you for sharing this wealth of information I wixh we had this caliber of doctor in the US. Wow I really appreciate this interview

@KathyPianoHarp 1 year ago

Brilliant discussion! So many keys to optimal aging. Thank you. I shall listen to this a second time & take notes of all the practical things I can do to affect my life trajectory.