We cover the complete reaction mechanism for E2 (biomolecular elimination) in organic chemistry: mechanism, Zaitsev's Rule for determining major products, when Zaitsev's Rule FAILS (Hofmann Elimination), and tricky cases like cyclic structures and choosing the major product between a pair of cis/trans isomers. (Zaitsev's Rule is also called Zaytsev's Rule, Saytzeff's Rule, or Saytzev's Rule.)

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0:00 Bimolecular Elimination Reactions
0:25 E2 Overall Equation
1:45 E2 Generic Pattern
4:29 Symmetrical (Easier) Example
6:42 Zaitsev's Rule Example
9:53 Hofmann Elimination (4 Exceptions to Zaitsev's Rule)
10:16 1 Conjugated Double Bond Systems
11:35 2 Bulky Bases
12:17 3 Leaving Group is too Basic
13:31 Fluorides...
13:54 4 Anti- & Syn-
16:42 Cyclic Systems
20:51 cis- vs trans- Major & Minor Products
21:31 Newman Projection Leading to Major Product
22:28 Newman Projection Leading to Minor Product
22:58 Why these lead to major vs minor
24:23 Newman Projections You Can Ignore
25:26 & when you can't ignore

Citations:
Paula Yurkanis Bruice, "Organic Chemistry" 8th ed
Chapter 9, base reactivity data from table 9.5
https://openstax.org/details/books/or...
https://openstax.org/details/books/ch...

Music:  Electron Clouds with a Chance of Swing