Monther Abu-Remaileh | Intra-lysosomal lipid metabolism and neurodegeneration
American Society for Biochemistry and Molecular Biology (ASBMB)
643 views
Monther Abu–Remaileh leads a lab at Stanford University advancing the field of lysosomal lipid biochemistry. For this work, he won the American Society for Biochemistry and Molecular Biology's 2026 Walter A. Shaw Young Investigator Award in Lipid Research.
His lab focuses on how lysosomal dysfunction contributes to neurodegenerative disease. They began by studying conditions with known genetic causes but unclear biological mechanisms, systematically knocking out genes to see how they affected the lysosome. The team used mass spectrometry to measure changes in lipids, metabolites and proteins and found striking shifts in lysosomal lipids linking altered lipid metabolism to neurodegeneration.
One of the lab’s key discoveries centers on the ceroid-lipofuscinosis neuronal 5 gene, or CLN5. Loss of this gene causes a severe childhood neurodegenerative disorder, and variants in CLN5 also increase Alzheimer’s risk.
⏯️ This talk, "Intra-lysosomal lipid metabolism and neurodegeneration" was delivered on March 10 at the 2026 ASBMB Annual Meeting at National Harbor, just outside of Washington, D.C.
➡️ Learn more about Abu-Remaileh's work: https://www.asbmb.org/asbmb-today/peo....
🔬 Inspired? Share your expertise at the 2027 ASBMB Annual Meeting, April April 3–6, in Boston! Organize a mini-symposium, interest group session or workshop and help drive the dialogue at the forefront of the molecular life sciences. Learn more and submit a proposal: https://www.asbmb.org/annual-meeting/....
Monther Abu-Remaileh | Intra-lysosomal lipid metabolism and neurodegeneration
American Society for Biochemistry and Molecular Biology (ASBMB)
643 views
Monther Abu–Remaileh leads a lab at Stanford University advancing the field of lysosomal lipid biochemistry. For this work, he won the American Society for Biochemistry and Molecular Biology's 2026 Walter A. Shaw Young Investigator Award in Lipid Research.
His lab focuses on how lysosomal dysfunction contributes to neurodegenerative disease. They began by studying conditions with known genetic causes but unclear biological mechanisms, systematically knocking out genes to see how they affected the lysosome. The team used mass spectrometry to measure changes in lipids, metabolites and proteins and found striking shifts in lysosomal lipids linking altered lipid metabolism to neurodegeneration.
One of the lab’s key discoveries centers on the ceroid-lipofuscinosis neuronal 5 gene, or CLN5. Loss of this gene causes a severe childhood neurodegenerative disorder, and variants in CLN5 also increase Alzheimer’s risk.
⏯️ This talk, "Intra-lysosomal lipid metabolism and neurodegeneration" was delivered on March 10 at the 2026 ASBMB Annual Meeting at National Harbor, just outside of Washington, D.C.
➡️ Learn more about Abu-Remaileh's work: https://www.asbmb.org/asbmb-today/peo....
🔬 Inspired? Share your expertise at the 2027 ASBMB Annual Meeting, April April 3–6, in Boston! Organize a mini-symposium, interest group session or workshop and help drive the dialogue at the forefront of the molecular life sciences. Learn more and submit a proposal: https://www.asbmb.org/annual-meeting/....