Today on The Dhru Purohit Show, I sit down with Dr. David Perlmutter to explore why decades of brain health research may have focused on the wrong target. Dr. Perlmutter explains why microglial cells, not beta-amyloid, are emerging as the key drivers of brain health, how they reflect your metabolic health, and what you can do in your 30s and 40s to help prevent cognitive decline. He also shares why many Alzheimer's drugs have missed the mark, the supplements with the strongest evidence for protecting the brain, and the lifestyle habits that put you in control of your long-term cognitive health, and what you can start doing today, regardless of age, to protect your cognitive health for years to come.

Dr. David Perlmutter is a board-certified neurologist, Fellow of the American College of Nutrition, and six-time New York Times bestselling author, best known for Grain Brain and Drop Acid. He earned his M.D. from the University of Miami School of Medicine, where he received the Leonard G. Rowntree Research Award, and currently serves as an Associate Professor at the University of Miami Miller School of Medicine. Dr. Perlmutter has published extensively in leading peer-reviewed medical journals, serves on the Editorial Board of the Journal of Alzheimer's Disease, and lectures worldwide on brain health, nutrition, and longevity.

In this episode, Dhru and Dr. Perlmutter dive into:

(0:00) The Biggest Mistake in Brain Health
(2:27) The Brain Cells That Control Your Future
(4:19) Why Microglia Are Suddenly Everywhere
(7:55) Dr. Perlmutter’s Controversial Claim
(11:09) Decline May Begin Decades Earlier
(18:01) When Your Brain's Defenders Turn Against You
(20:21) The Gut-Brain Connection
(31:18) The Hidden Chemical Linked to Damage
(35:07) Why Modern Life Is Rewiring Your Brain
(38:40) Are Microplastics Harming Your Brain?
(42:15) The Best Forms of Exercise
(52:47) The Key Biomarkers
(57:01) The Brain-Protective Diet Most People Ignore
(1:09:13) Top Supplements to Support Brain Health
(1:15:59) Building a Resilient Brain
(1:24:18) Has the Science on Alcohol Changed?
(1:29:47) What to Do If You're Already at Risk
(1:36:23) Could GLP-1s Protect the Brain?
(1:45:05) Final Thoughts

Also mentioned in this episode:
-Brain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life: https://a.co/d/01YEOKwD
-Lichen Air: https://lichenair.com/

For more on Dr. Perlmutter, follow him on:
-Facebook: Facebook: DavidPerlmutterMd
-X/Twitter: Twitter: davidperlmutter
-Instagram: Twitter: davidperlmutter
-YouTube: davidperlmuttermd
-Website: https://drperlmutter.com/

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