AIIMS November 2018 Pharmacology Solution
Ranjan Kumar Patel
15,508 views
Solution to the pharmacology questions asked in AIIMS November 2018 exam by Dr. Ranjan Kumar Patel
1. Dose reduction is required in renal failure with all except
a. Amphotericin B
b. Vancomycin
c. Doxycycline
d. Gentamicin
Ans is ‘c’, Doxycycline
2. Side effects of salbutamol are all except
a. Hypokalemia
b. Hypoglycemia
c. Tremor
d. Tachycardia
Ans is ‘b’, Hypoglycemia
3. Loading dose depends on
a. Volume of distribution
b. Bioavailability
c. Half-life
d. Clearance
Ans is ‘a’, Volume of distribution
4. Low apparent volume of distribution indicates
a. Drug is not extensively distributed in organs and tissues
b. Low bioavailability
c. Low T 1/2
d. Very low efficacy
Ans is ‘a’, Drug is not extensively distributed in organs and tissues
5. Pediatrician attended infant with unconjugated serum bilirubin level of 33mg/dL. Which drug mother might have taken in 3rd trimester
a. Azithromycin
b. Chloroquine
c. Ampicillin
d. Cotrimoxazole
Ans is d, Cotrimoxazole
6. For a patient of hypertension on metoprolol, verapamil was given; this will result in
a. Atrial fibrillation
b. Bradycardia with AV block
c. Torsades de pointes
d. Tachycardia
Ans is ‘b’, Bradycardia with AV block
7. Mechanism by which Ach decreases heart rate is by
a. Delayed diastolic depolarization
b. Increase in plateau
c. Decrease preload
d. Increase afterload
Ans is ‘a’, Delayed diastolic depolarization
8. Diamox is given for glaucoma, which is a noncompetitive antagonist of carbonic anhydrase. The effect is
a. Increase in Km and Vmax
b. Decrease in Km
c. Decrease in Vmax
d. No change in Vmax
Ans is ‘c’, Decrease in Vmax
9. Which is gametocidal for all species
a. Quinine
b. Chloroquine
c. Primaquine
d. None
Ans is ‘c’, Primaquine
10. A Male with insulin dependent diabetes having macular edema develops glaucoma. Which drug should be used as the least resort to treat.
a. Alpha agonist
b. Prostaglandin analogue
c. Pilocarpine
d. Beta blocker
Ans is ‘b’, Prostaglandin analogue
11. Lithium use in pregnancy leads to which effect on baby?
a. CVS defect
b. Urogenital defect
c. Neural tube defect
d. Facial defects
Ans is ‘a’, CVS defect
12. If carbamazepine is added to valproate, which of the following side-effect increases?
a. Thrombocytopenia
b. Hepatotoxicity
c. Hyperammonemia
d. Pancreatitis
Ans is ‘b’, Hepatotoxicity
13. Which of the following drug is used to prevent acute mountain sickness
a. Acetazolamide
b. Dexamethasone
c. Diltiazem
d. Digoxin
Ans is ‘a’, Acetazolamide
14. A known case of TB is now resistant to Rifampicin and Isoniazid. Which of the following would be most appropriate in treating this patient?
A. 6 drugs for 4months; 4 drugs for 12 months
B. 6 drugs for 6 months; 4 drugs for 18 months
C. 4 drugs for 4 months, 6 drugs for 12 months
D. 5 drugs 2 months; 4 drug 1 month; 3 drug 5 months
Ans is ‘b’, B. 6 drugs for 6 months; 4 drugs for 18 months
15. Schedule of drug to be sold only on prescription is
a. H
b. P
c. G
d. X
Ans is ‘a’, H
16. In a rheumatic heart disease pregnant female with prosthetic valve, when should we switch to heparin
a. 32 weeks
b. 36 weeks
c. 37 weeks
d. 40 weeks
Ans is ‘c’, 37 weeks
17. Phase I trial is done to test
a. Safety
b. Efficacy
c. Dose
d. Pharmacokinetics
Ans is ‘d’, Pharmacokinetics
18. Nitroprusside active metabolite act by
a. Phosphokinase 1,2
b. Guanylyl cyclase
c. Phospholipase A
d. Phospholipase B
Ans is ‘b’, Guanylyl cyclase
19. Dapsone is used as antibacterial, antifungal and as an immunomodulator. what is the mechanism behind all these actions?
a. Inhibition of cell wall synthesis
b. Inhibition of sterol of the cell wall
c. Inhibition of protein synthesis in ribosomes
d. Competes with PABA in folic acid synthesis
Ans is ‘d’, Competes with PABA in folic acid synthesis
20. The kit in the picture is used for treatment of
21. Morphine should not be given in a patient with:
a. Ischemic pain
b. Cancer pain
c. Biliary colic
d. Postoperative pain
Ans is ‘c’, Biliary colic
22. A patient is on indinavir, zidovudine, lamivudine and ketoconazole. He developed breast hypertrophy, nephrolithiasis, hyperlipidemia and central obesity; identify the drug causing these side effects amongst all:
a. Lamivudine
b. Indinavir
c. Ketoconazole
d. Zidovudine
Ans is ‘b’, Indinavir
23. Which of the following is correct regarding T3 and T4 acting on TRH?
a. It activates Phospholipase A
b. It acts on transcription factor
c. It acts by increasing cAMP
d. It is a tyrosine kinase receptor
Ans is ‘b’, It acts on transcription factor
24. A 16 year old girl was on antiepileptic for treatment of seizure episodes while asleep. She had no seizure for 6 months and NCCT and EEG was normal. What is further management?
a. Stop treatment
b. Continue for 2 years
c. Life long treatment
d. Stop treatment and follow up with 6 monthly EEG
Ans is ‘c’, Life long treatment
20 Comments
😂4. Low apparent volume of distribution indicates. 13:53
😂Pediatrician attended infant with unconjugated serum bilirubin level
of 33mg/dL. Which drug mother might have taken in 3rd trimester. 16:54
😂6. For a patient of hypertension on metoprolol, verapamil was given;
this will result in. 20:34
😂Mechanism by which Ach decreases heart rate is by. 21:15
😂8. Diamox is given for glaucoma, which is a noncompetitive antagonist
of carbonic anhydrase. The effect is. 28:26
😂9. Which is gametocidal for all species. 32:25
😂10. A Male with insulin dependent diabetes having macular edema develops glaucoma. Which drug should be used as the least resort to. 34:37
😂11. Lithium use in pregnancy leads to which effect on baby?
a. CVS defect. 36:17
😂14. A known case of TB is now resistant to Rifampicin and Isoniazid.
Which of the following would be most appropriate in treating this. 46:02
😂15. Schedule of drug to be sold only on prescription is
a. H. 47:12
😂17. Phase I trial is done to test. 57:45
😂18. Nitroprusside active metabolite act by
a
Phosphokinase. 1:00:08
😂19. Dapsone is used as antibacterial, antifungal and as an
immunomodulator. what is the mechanism behind all these actions? 1:03:04
😂21. Morphine should not be given in a patient with:
a. Ischemic nain. 1:09:25
😂22. A patient is on indinavir, zidovudine, lamivudine and ketoconazole
He developed breast hypertrophy, nephrolithiasis, hyperlipidemia and
central obesity: identify the drug causing these side effects amongst. 1:10:07
😂23. Which of the following is correct regarding T3 and T4 acting on TRH?
a. It activates Phospholipase A. 1:11:10
😂24. A 16 year old girl was on antiepileptic for treatment of seizure
episodes while asleep. She had no seizure for 6 months and NCCT and EEG was normal. What is further management. 1:16:43
😂26. All of the following drugs increase bleeding when given to a
patient on warfarin EXCEPT: 1:19:06
😂27. Primary action of nitrates in a patient of angina is. 1:20:22
😂28. The technique given in the picture is used for. 1:22:01
😂
Wish few more important topics & last year xams pharma solved qs are available here.
Your conceptual teaching strengthens our pharma basics that will help us in a long way in clinical practice too.
Heartfelt thanks for all your efforts & most importantly for making us better doctors Sir.
AIIMS November 2018 Pharmacology Solution
Ranjan Kumar Patel
15,508 views
Solution to the pharmacology questions asked in AIIMS November 2018 exam by Dr. Ranjan Kumar Patel
1. Dose reduction is required in renal failure with all except
a. Amphotericin B
b. Vancomycin
c. Doxycycline
d. Gentamicin
Ans is ‘c’, Doxycycline
2. Side effects of salbutamol are all except
a. Hypokalemia
b. Hypoglycemia
c. Tremor
d. Tachycardia
Ans is ‘b’, Hypoglycemia
3. Loading dose depends on
a. Volume of distribution
b. Bioavailability
c. Half-life
d. Clearance
Ans is ‘a’, Volume of distribution
4. Low apparent volume of distribution indicates
a. Drug is not extensively distributed in organs and tissues
b. Low bioavailability
c. Low T 1/2
d. Very low efficacy
Ans is ‘a’, Drug is not extensively distributed in organs and tissues
5. Pediatrician attended infant with unconjugated serum bilirubin level of 33mg/dL. Which drug mother might have taken in 3rd trimester
a. Azithromycin
b. Chloroquine
c. Ampicillin
d. Cotrimoxazole
Ans is d, Cotrimoxazole
6. For a patient of hypertension on metoprolol, verapamil was given; this will result in
a. Atrial fibrillation
b. Bradycardia with AV block
c. Torsades de pointes
d. Tachycardia
Ans is ‘b’, Bradycardia with AV block
7. Mechanism by which Ach decreases heart rate is by
a. Delayed diastolic depolarization
b. Increase in plateau
c. Decrease preload
d. Increase afterload
Ans is ‘a’, Delayed diastolic depolarization
8. Diamox is given for glaucoma, which is a noncompetitive antagonist of carbonic anhydrase. The effect is
a. Increase in Km and Vmax
b. Decrease in Km
c. Decrease in Vmax
d. No change in Vmax
Ans is ‘c’, Decrease in Vmax
9. Which is gametocidal for all species
a. Quinine
b. Chloroquine
c. Primaquine
d. None
Ans is ‘c’, Primaquine
10. A Male with insulin dependent diabetes having macular edema develops glaucoma. Which drug should be used as the least resort to treat.
a. Alpha agonist
b. Prostaglandin analogue
c. Pilocarpine
d. Beta blocker
Ans is ‘b’, Prostaglandin analogue
11. Lithium use in pregnancy leads to which effect on baby?
a. CVS defect
b. Urogenital defect
c. Neural tube defect
d. Facial defects
Ans is ‘a’, CVS defect
12. If carbamazepine is added to valproate, which of the following side-effect increases?
a. Thrombocytopenia
b. Hepatotoxicity
c. Hyperammonemia
d. Pancreatitis
Ans is ‘b’, Hepatotoxicity
13. Which of the following drug is used to prevent acute mountain sickness
a. Acetazolamide
b. Dexamethasone
c. Diltiazem
d. Digoxin
Ans is ‘a’, Acetazolamide
14. A known case of TB is now resistant to Rifampicin and Isoniazid. Which of the following would be most appropriate in treating this patient?
A. 6 drugs for 4months; 4 drugs for 12 months
B. 6 drugs for 6 months; 4 drugs for 18 months
C. 4 drugs for 4 months, 6 drugs for 12 months
D. 5 drugs 2 months; 4 drug 1 month; 3 drug 5 months
Ans is ‘b’, B. 6 drugs for 6 months; 4 drugs for 18 months
15. Schedule of drug to be sold only on prescription is
a. H
b. P
c. G
d. X
Ans is ‘a’, H
16. In a rheumatic heart disease pregnant female with prosthetic valve, when should we switch to heparin
a. 32 weeks
b. 36 weeks
c. 37 weeks
d. 40 weeks
Ans is ‘c’, 37 weeks
17. Phase I trial is done to test
a. Safety
b. Efficacy
c. Dose
d. Pharmacokinetics
Ans is ‘d’, Pharmacokinetics
18. Nitroprusside active metabolite act by
a. Phosphokinase 1,2
b. Guanylyl cyclase
c. Phospholipase A
d. Phospholipase B
Ans is ‘b’, Guanylyl cyclase
19. Dapsone is used as antibacterial, antifungal and as an immunomodulator. what is the mechanism behind all these actions?
a. Inhibition of cell wall synthesis
b. Inhibition of sterol of the cell wall
c. Inhibition of protein synthesis in ribosomes
d. Competes with PABA in folic acid synthesis
Ans is ‘d’, Competes with PABA in folic acid synthesis
20. The kit in the picture is used for treatment of
21. Morphine should not be given in a patient with:
a. Ischemic pain
b. Cancer pain
c. Biliary colic
d. Postoperative pain
Ans is ‘c’, Biliary colic
22. A patient is on indinavir, zidovudine, lamivudine and ketoconazole. He developed breast hypertrophy, nephrolithiasis, hyperlipidemia and central obesity; identify the drug causing these side effects amongst all:
a. Lamivudine
b. Indinavir
c. Ketoconazole
d. Zidovudine
Ans is ‘b’, Indinavir
23. Which of the following is correct regarding T3 and T4 acting on TRH?
a. It activates Phospholipase A
b. It acts on transcription factor
c. It acts by increasing cAMP
d. It is a tyrosine kinase receptor
Ans is ‘b’, It acts on transcription factor
24. A 16 year old girl was on antiepileptic for treatment of seizure episodes while asleep. She had no seizure for 6 months and NCCT and EEG was normal. What is further management?
a. Stop treatment
b. Continue for 2 years
c. Life long treatment
d. Stop treatment and follow up with 6 monthly EEG
Ans is ‘c’, Life long treatment
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